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A Case of Recurrent Malignant Pheochromocytoma Complicated by Watery Diarrhea, Hypokalemia, Achlorhydria Syndrome

Department of Urology (K.N., T.S., H. T., T.F.) and First Department of Pathology (S. Y.), Hirosaki University School of Medicine Hirosaki 036
Oyokyo Kidney Research Institute (K. Y., Y. T.) Hirosaki 036
The Endocrinology Division, National Cancer Center Research Institute (K. Y.) Tokyo 104, Japan

Address requests for reprints to: Tomihisa Funyu, M.D., Department of Urology, Hirosaki University School of Medicine, 5 Zaifu-Cho, Hirosaki 036, Japan.

A patient is reported who had undergone right adrenalectomy for pheochromocytoma and 15 yr later developed a recurrence in the same site complicated by the watery diarrhea, hypokalemia, achlorhydria syndrome. This tumor was histologically defined as a composite malignant pheochromocytomaganglioneuroblastoma (well differentiated type). Vasoactive intestinal polypeptide and catecholamine concentrations were elevated in both plasma and the tumor. The tumor somatostatin content also was high. The tumor was immunohistochemically determined to contain both vasoactive intestinal polypeptide and somatostatin.

Received February 9, 1987.

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