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Journal of Clinical Endocrinology & Metabolism, Vol 65, 1053-1056, Copyright © 1987 by Endocrine Society

ARTICLES

A case of recurrent malignant pheochromocytoma complicated by watery diarrhea, hypokalemia, achlorhydria syndrome

K Nigawara, T Suzuki, H Tazawa, T Funyu, S Yagihashi, K Yamaya, Y Terayama and K Yamaguchi
Department of Urology, Hirosaki University School of Medicine, Japan.

A patient is reported who had undergone right adrenalectomy for pheochromocytoma and 15 yr later developed a recurrence in the same site complicated by the watery diarrhea, hypokalemia, achlorhydria syndrome. This tumor was histologically defined as a composite malignant pheochromocytoma-ganglioneuroblastoma (well differentiated type). Vasoactive intestinal polypeptide and catecholamine concentrations were elevated in both plasma and the tumor. The tumor somatostatin content also was high. The tumor was immunohistochemically determined to contain both vasoactive intestinal polypeptide and somatostatin.




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Copyright © 1987 by The Endocrine Society