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Effect of Short Term Triiodothyronine Administration on Human Leukocyte Rb(K) Influx and Na Efflux

Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine London, United Kingdom

Address all correspondence and requests for reprints to: Dr. P. Dandona, Metabolic Unit, Department of Chemical Pathology and Human Metabolism, Royal Free Hospital, Pond Street, London, NW3 2QG United Kingdom.

The effect of short term T₃ administration on leukocyte ouabain-sensitive ⁸⁶Rb(K) influx and Na efflux in normal subjects was investigated. At a dose of 60 µg daily for 7 days, T₃ induced a significant increase in leukocyte ⁸⁶Rb(K) influx and a significant fall in plasma K concentrations. Plasma and intracellular Na concentrations did not change. [³H]Ouabain binding, a measure of Na-K ATPase units, did not change. A week after T₃ administration, ⁸⁶Rb(K) influx, Na efflux, and plasma K concentrations were normal. In a series of five hyperthyroid patients, both ouabain-sensitive ⁸⁶Rb influx and [³H] ouabain binding were significantly greater than in normal subjects. We conclude that T₃ stimulates ⁸⁶Rb(K) influx and Na efflux by leukocytes in vivo independently of [3H]ouabain binding and that this increase is rapidly reversible. However, in hyperthyroid patients both ⁸⁶Rbinflux and [³H] ouabain binding are increased, probably due to prolonged exposure to thyroid hormone excess.

^* Supported by a fellowship from the government of Iraq.

Received May 5, 1987.

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