| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Journal of Clinical Endocrinology & Metabolism, Vol 65, 757-764, Copyright © 1987 by Endocrine Society
ARTICLES |
N Fournet-Dulguerov, NJ MacLusky, CZ Leranth, R Todd, CR Mendelson, ER Simpson and F Naftolin
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06510.
Immunohistochemistry employing immunoglobulin G fractions raised against aromatase cytochrome P-450 and antiserum against 17 beta- estradiol dehydrogenase was used to localize these two steroid- converting enzymes in the human placenta. Immunostaining for both enzymes was found exclusively in the syncytiotrophoblast, while the underlying cytotrophoblast and the villus core did not stain. Ultrastructural examination of aromatase cytochrome P-450- and 17 beta- estradiol dehydrogenase-labeled sections disclosed immunoreactive product in the membranes of the endoplasmic reticulum; the nucleus, mitochondria, Golgi apparatus, and secretory granules were free of staining. These findings suggest that the syncytiotrophoblast is actively involved in the synthesis and metabolism of estrogens and in their role in placental endocrine function.
This article has been cited by other articles:
 |
|
 |
|
  O. Bukulmez, D. B. Hardy, B. R. Carr, R. A. Word, and C. R. Mendelson Inflammatory Status Influences Aromatase and Steroid Receptor Expression in Endometriosis Endocrinology, March 1, 2008; 149(3): 1190 - 1204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Saloniemi, T. Lamminen, K. Huhtinen, M. Welsh, P. Saunders, H. Kujari, and M. Poutanen Activation of Androgens by Hydroxysteroid (17{beta}) Dehydrogenase 1 in Vivo as a Cause of Prenatal Masculinization and Ovarian Benign Serous Cystadenomas Mol. Endocrinol., November 1, 2007; 21(11): 2627 - 2636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kamat, M. E. Smith, J. M. Shelton, J. A. Richardson, and C. R. Mendelson Genomic Regions that Mediate Placental Cell-Specific and Developmental Regulation of Human Cyp19 (Aromatase) Gene Expression in Transgenic Mice Endocrinology, May 1, 2005; 146(5): 2481 - 2488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kasai, M. Shozu, K. Murakami, T. Segawa, K. Shinohara, K. Nomura, and M. Inoue Increased Expression of Type I 17{beta}-Hydroxysteroid Dehydrogenase Enhances in Situ Production of Estradiol in Uterine Leiomyoma J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5661 - 5668. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Husen, J. Adamski, A. Bruns, D. Deluca, K. Fuhrmann, G. Moller, I. Schwabe, and A. Einspanier Characterization of 17{beta}-Hydroxysteroid Dehydrogenase Type 7 in Reproductive Tissues of the Marmoset Monkey Biol Reprod, June 1, 2003; 68(6): 2092 - 2099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bonenfant, C. H. Blomquist, P. R. Provost, R. Drolet, P. D’Ascoli, and Y. Tremblay Tissue- and Site-Specific Gene Expression of Type 2 17{beta}-Hydroxysteroid Dehydrogenase: In Situ Hybridization and Specific Enzymatic Activity Studies in Human Placental Endothelial Cells of the Arterial System J. Clin. Endocrinol. Metab., December 1, 2000; 85(12): 4841 - 4850. [Abstract] [Full Text]
|
|
|
|
|
|
B. Jiang, A. Kamat, and C. R. Mendelson Hypoxia Prevents Induction of Aromatase Expression in Human Trophoblast Cells in Culture: Potential Inhibitory Role of the Hypoxia-Inducible Transcription Factor Mash-2 (Mammalian Achaete-Scute Homologous Protein-2) Mol. Endocrinol., October 1, 2000; 14(10): 1661 - 1673. [Abstract] [Full Text]
|
|
|
|
|
|
S. Leivonen, Y.-s. Piao, H. Peltoketo, P. Numchaisrika, R. Vihko, and P. Vihko Identification of Essential Subelements in the hHSD17B1 Enhancer: Difference in Function of the Enhancer and That of the hHSD17BP1 Analog Is due to -480C and -486G Endocrinology, August 1, 1999; 140(8): 3478 - 3487. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Kamat, K. H. Graves, M. E. Smith, J. A. Richardson, and C. R. Mendelson A 500-bp region, approx 40 kb upstream of the human CYP19 () gene, mediates placenta-specific expression in transgenic mice PNAS, April 13, 1999; 96(8): 4575 - 4580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Mensah-Nyagan, J.-L. Do-Rego, D. Beaujean, V. Luu-The, G. Pelletier, and H. Vaudry Neurosteroids: Expression of Steroidogenic Enzymes and Regulation of Steroid Biosynthesis in the Central Nervous System Pharmacol. Rev., March 1, 1999; 51(1): 63 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Sawicki, M. Erman, T. Puranen, P. Vihko, and D. Ghosh Structure of the ternary complex of human 17beta -hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+ PNAS, February 2, 1999; 96(3): 840 - 845. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kamat, J. L. Alcorn, C. Kunczt, and C. R. Mendelson Characterization of the Regulatory Regions of the Human Aromatase (P450arom) Gene Involved in Placenta-Specific Expression Mol. Endocrinol., November 1, 1998; 12(11): 1764 - 1777. [Abstract] [Full Text]
|
|
|
|
|
|
L. Dalla Valle, A. Ramina, S. Vianello, A. Fassina, P. Belvedere, and L. Colombo Potential for Estrogen Synthesis and Action in Human Normal and Neoplastic Thyroid Tissues J. Clin. Endocrinol. Metab., October 1, 1998; 83(10): 3702 - 3709. [Abstract] [Full Text]
|
|
|
|
|
|
J. Takeyama, H. Sasano, T. Suzuki, K. Iinuma, H. Nagura, and S. Andersson 17{beta}-Hydroxysteroid Dehydrogenase Types 1 and 2 in Human Placenta: An Immunohistochemical Study with Correlation to Placental Development J. Clin. Endocrinol. Metab., October 1, 1998; 83(10): 3710 - 3715. [Abstract] [Full Text]
|
|
|
|
|
|
P. Nokelainen, H. Peltoketo, R. Vihko, and P. Vihko Expression Cloning of a Novel Estrogenic Mouse 17{beta}-Hydroxysteroid Dehydrogenase/ 17-Ketosteroid Reductase (m17HSD7), Previously Described as a Prolactin Receptor-Associated Protein (PRAP) in Rat Mol. Endocrinol., July 1, 1998; 12(7): 1048 - 1059. [Abstract] [Full Text]
|
|
|
|
|
|
N. Moghrabi, J. R. Head, and S. Andersson Cell Type-Specific Expression of 17{beta}-Hydroxysteroid Dehydrogenase Type 2 in Human Placenta and Fetal Liver J. Clin. Endocrinol. Metab., November 1, 1997; 82(11): 3872 - 3878. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Penning Molecular Endocrinology of Hydroxysteroid Dehydrogenases Endocr. Rev., June 1, 1997; 18(3): 281 - 305. [Abstract] [Full Text]
|
|
|
|
|
|
Y.-s. Piao, H. Peltoketo, A. Jouppila, and R. Vihko Retinoic Acids Increase 17{beta}-Hydroxysteroid Dehydrogenase Type 1 Expression in JEG-3 and T47D Cells, but the Stimulation Is Potentiated by Epidermal Growth Factor, 12-O-Tetradecanoylphorbol-13-Acetate, and Cyclic Adenosine 3',5'-Monophosphate Only in JEG-3 Cells Endocrinology, March 1, 1997; 138(3): 898 - 904. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. R. Agarwal, C. I. Ashanullah, E. R. Simpson, and S. E. Bulun Alternatively Spliced Transcripts of the Aromatase Cytochrome P450 (CYP19) Gene in Adipose Tissue of Women J. Clin. Endocrinol. Metab., January 1, 1997; 82(1): 70 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Nichols, S. E. Bulun, and E. R. Simpson Effects of Conditioned Medium from Different Cultured Cell Types on Aromatase Expression in Adipose Stromal Cells Reproductive Sciences, January 1, 1995; 2(1): 45 - 50. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
