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Perinatal Serum Bone Gla-Protein and Vitamin D Metabolites in Preterm and Fullterm Neonates^*

INSERM U.234, Hôpital E. Her riot (P.D.D.), and the Department of Neonatology, Uniuersité Claude Bernard (B.L.S., I.M.) Lyon, France
The Genetics Unit, Shriners Hospital, and the Departments Surgery and Pediatrics, McGill University (F.H.G., E.E.D.) Montreal, Canada

Address all correspondence and requests for reprints to: Dr. Pierre Delmas, Hôpital Edouard Herriot, Pavilion E, 69437 Lyon Cedex 03, France.

Whether the hypocalcemia often found in premature neonates results from an adaptation to extrauterine life or an expression of imbalanced mineral homeostasis has yet to be established. We compared serum levels of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D [1,25-(OH)₂D], and bone Gla-protein (BGP), a specific marker of bone formation during the first month of life in fullterm and preterm neonates. Measurements were performed in cord blood and on days 1, 5, and 30 of life. In maternal blood, mean serum 1,25-(OH)₂D concentrations were higher in the mothers of premature than in those of fullterm neonates, and serum BGP concentrations were lower than those i n nonpregnant women. In cord blood mean serum BGP levels were 2–3 times higher than in adults. Serum BGP increased significantly on days 5 and 30 in fullterm infants. In preterm infants, an increase was found only on day 30. Mean serum 25-hydroxyvitamin D and 1,25-(OH)₂D concentrations were lower in neonates than in mothers, but not different in fullterm and preterm neonates. In fullterm infants serum 1,25-(OH)₂D increased rapidly from birth to day 5 and decreased on day 30. The pattern was similar in preterm infants, but 1,25-(OH)₂D was higher than in fullterm infants on day 30. No sustained correlation between serum BGP and 1,25-(OH)₂D levels wasfound. These data support the contention that changes in 1,25-(OH)2D reflect the perinatal equilibration of calcium homeostasis. Serum BGP may be a potential marker of bone growth in premature neonates.

^* This work was supported in part by the Compagnie ORIS Industrie (Contracts R098520 and R098562), INSERM Contract 930-696, and the Shriners of North America.

Received January 8, 1987.

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