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Journal of Clinical Endocrinology & Metabolism Vol. 65, No. 3 581-584
doi:10.1210/jcem-65-3-581
Copyright © 1987 by the Endocrine Society.
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Magnetic Resonance Imaging of the Brain in Patients with Anosmia and Hypothalamic Hypogonadism (Kallmann's Syndrome)*

DIETRICH KLINGMÜLLER, WERNER DEWES, THOMAS KRAHE, GISELA BRECHT and HANS-UDO SCHWEIKERT

Department of Internal Medicine and Radiology, University of Bonn Bonn, West Germany

Address requests for reprints to: Dr. Dietrich Klingmüller, fur Klinische Biochemie, Sigmund-Freud-Str 25, D 5300 Bonn, West Germany.

Kallmann's syndrome is characterized by hypo-gonadotropic hypogonadism and anosmia. Postmortem studies have revealed either hypoplasia or aplasia of the rhinencephalon, respectively, in patients with hyposmia and anosmia. This anatomical defect has now been demonstrated in vivo in four patients with Kallmann's syndrome by magnetic resonance imaging.

* This work was supported by the Deutsche Forschungsgemeinschaft (Schw 168/5–6) and was presented in part at the 92. Tagung der Deutschen Gesellschaft für innere Medizin, Wiesbaden, West Germany, 1986.

Received June 26, 1986.




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