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Journal of Clinical Endocrinology & Metabolism, Vol 65, 370-371, Copyright © 1987 by Endocrine Society

ARTICLES

Insulin-like growth factor-I modulates endothelial cell chemotaxis

M Grant, J Jerdan and TJ Merimee

Insulin-like growth factor-I (IGF-I) significantly promoted chemotaxis in three separate endothelial cell lines at concentrations ranging from 4 to 150 ng/ml. When added to minimum essential medium (MEM) supplemented with 1% fetal calf serum, IGF-I augmented chemotaxis to a level equalling the maximal chemotactic effect obtainable with MEM supplemented with 10% fetal calf serum (FCS 10%). The data are compatible with a potential role for IGF-I in neovascularization.


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