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Journal of Clinical Endocrinology & Metabolism, Vol 65, 194-197, Copyright © 1987 by Endocrine Society

ARTICLES

Norethindrone inhibition of testosterone secretion by an ovarian Sertoli-Leydig cell tumor

JR Brumsted, J Chapitis, D Riddick and M Gibson

A woman with severe hyperandrogenemia and virilization was found to have a fall in serum testosterone (T) concentration while taking an oral contraceptive containing norethindrone (500 vs. 164 ng/dL). Subsequent surgical exploration revealed an ovarian Sertoli-Leydig cell tumor. In vitro, the tumor secreted T (mean, 1.88 ng/mg X 4 h). hCG did not stimulate T secretion. In addition, norethindrone inhibited T secretion (0.33 ng/mg X 4 h). We conclude that norethindrone directly suppressed T production by the Sertoli-Leydig cell tumor.


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R. B. Barnes and D. A. Ehrmann
Long-Term Suppression of Testosterone After Treatment with a Gonadotropin-Releasing Hormone Agonist in a Woman with a Presumed Testosterone Secreting Ovarian Tumor
J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1746 - 1748.
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