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Journal of Clinical Endocrinology & Metabolism, Vol 64, 1320-1322, Copyright © 1987 by Endocrine Society

ARTICLES

Short term administration of gonadotropin-releasing hormone analog to a patient with a testosterone-secreting ovarian tumor

L Kennedy, AI Traub, AB Atkinson and B Sheridan

A GnRH superagonist, buserelin, was administered for 16 days to a postmenopausal woman with a testosterone-secreting ovarian tumor. Serum gonadotropin levels decreased by more than 70%, and serum testosterone fell by more than 50%. This short term study demonstrates that in these uncommon tumors androgen secretion is gonadotropin sensitive, and suggests that GnRH analogs may have therapeutic value in such patients.


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R.T. Netea-Maier, W.-A. Nieuwlaat, C.G.J. Sweep, P. Wesseling, L. Massuger, and A.R.M.M. Hermus
Virilization due to ovarian androgen hypersecretion in a patient with ectopic adrenocorticotrophic hormone secretion caused by a carcinoid tumour: Case Report
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R. B. Barnes and D. A. Ehrmann
Long-Term Suppression of Testosterone After Treatment with a Gonadotropin-Releasing Hormone Agonist in a Woman with a Presumed Testosterone Secreting Ovarian Tumor
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