help button home button Endocrine Society JCEM ENDO 08
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hauner, H.
Right arrow Articles by Pfeiffer, E. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hauner, H.
Right arrow Articles by Pfeiffer, E. F.

Journal of Clinical Endocrinology & Metabolism, Vol 64, 832-835, Copyright © 1987 by Endocrine Society

ARTICLES

Glucocorticoids and insulin promote the differentiation of human adipocyte precursor cells into fat cells

H Hauner, P Schmid and EF Pfeiffer

To study the in vitro differentiation of human adipocyte precursor cells and its regulation by hormones, primary cultures of stromal vascular cells of human adipose tissue were established. A 30- to 70- fold increase in the number of developing fat cells was achieved by the addition of cortisol or related corticosteroids in the presence of insulin. Either of the two hormones alone was ineffective. The stimulatory action of cortisol was dose dependent and occurred at physiological concentrations. The results suggest that glucocorticoids may play a role in the development of human hyperplastic obesity by stimulating the formation of adipocytes from precursor cells.


This article has been cited by other articles:


Home page
 J EndocrinolHome page
D. P Macfarlane, S. Forbes, and B. R Walker
Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome
J. Endocrinol., May 1, 2008; 197(2): 189 - 204.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
I J Bujalska, L L Gathercole, J W Tomlinson, C Darimont, J Ermolieff, A N Fanjul, P A Rejto, and P M Stewart
A novel selective 11{beta}-hydroxysteroid dehydrogenase type 1 inhibitor prevents human adipogenesis
J. Endocrinol., May 1, 2008; 197(2): 297 - 307.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. A. De Sousa Peixoto, S. Turban, J. H. Battle, K. E. Chapman, J. R. Seckl, and N. M. Morton
Preadipocyte 11{beta}-Hydroxysteroid Dehydrogenase Type 1 Is a Keto-Reductase and Contributes to Diet-Induced Visceral Obesity in Vivo
Endocrinology, April 1, 2008; 149(4): 1861 - 1868.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. Shrivastav, T. Kino, T. Cunningham, T. Ichijo, U. Schubert, P. Heinklein, G. P. Chrousos, and J. B. Kopp
Human Immunodeficiency Virus (HIV)-1 Viral Protein R Suppresses Transcriptional Activity of Peroxisome Proliferator-Activated Receptor {gamma} and Inhibits Adipocyte Differentiation: Implications for HIV-Associated Lipodystrophy
Mol. Endocrinol., February 1, 2008; 22(2): 234 - 247.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. L. Gathercole, I. J. Bujalska, P. M. Stewart, and J. W. Tomlinson
Glucocorticoid Modulation of Insulin Signaling in Human Subcutaneous Adipose Tissue
J. Clin. Endocrinol. Metab., November 1, 2007; 92(11): 4332 - 4339.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
E. Dos Santos, M.-N. Dieudonne, M.-C. Leneveu, R. Pecquery, V. Serazin, and Y. Giudicelli
In vitro effects of chorionic gonadotropin hormone on human adipose development
J. Endocrinol., August 1, 2007; 194(2): 313 - 325.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. Jang, V. R. Obeyesekere, R. J. Dilley, Z. Krozowski, W. J. Inder, and F. P. Alford
Altered Activity of 11{beta}-Hydroxysteroid Dehydrogenase Types 1 and 2 in Skeletal Muscle Confers Metabolic Protection in Subjects with Type 2 Diabetes
J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3314 - 3320.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
J. G. Noll, M. H. Zeller, P. K. Trickett, and F. W. Putnam
Obesity Risk for Female Victims of Childhood Sexual Abuse: A Prospective Study
Pediatrics, July 1, 2007; 120(1): e61 - e67.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
S. Kidambi, J. M. Kotchen, C. E. Grim, H. Raff, J. Mao, R. J. Singh, and T. A. Kotchen
Association of Adrenal Steroids With Hypertension and the Metabolic Syndrome in Blacks
Hypertension, March 1, 2007; 49(3): 704 - 711.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
I. J Bujalska, O. M Durrani, J. Abbott, C. U Onyimba, P. Khosla, A. H Moosavi, T. T Q Reuser, P. M Stewart, J. W Tomlinson, E. A Walker, et al.
Characterisation of 11{beta}-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat
J. Endocrinol., February 1, 2007; 192(2): 279 - 288.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. Darmon, F. Dadoun, S. Boullu-Ciocca, M. Grino, M.-C. Alessi, and A. Dutour
Insulin resistance induced by hydrocortisone is increased in patients with abdominal obesity
Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E995 - E1002.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
I J Bujalska, M Quinkler, J W Tomlinson, C T Montague, D M Smith, and P M Stewart
Expression profiling of 11{beta}-hydroxysteroid dehydrogenase type-1 and glucocorticoid-target genes in subcutaneous and omental human preadipocytes.
J. Mol. Endocrinol., October 1, 2006; 37(2): 327 - 340.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. L. Turgeon, M. C. Carr, P. M. Maki, M. E. Mendelsohn, and P. M. Wise
Complex Actions of Sex Steroids in Adipose Tissue, the Cardiovascular System, and Brain: Insights from Basic Science and Clinical Studies
Endocr. Rev., October 1, 2006; 27(6): 575 - 605.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. K. Paulsen, S. B. Pedersen, J. O. L. Jorgensen, S. Fisker, J. S. Christiansen, A. Flyvbjerg, and B. Richelsen
Growth Hormone (GH) Substitution in GH-Deficient Patients Inhibits 11{beta}-Hydroxysteroid Dehydrogenase Type 1 Messenger Ribonucleic Acid Expression in Adipose Tissue
J. Clin. Endocrinol. Metab., March 1, 2006; 91(3): 1093 - 1098.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. S. Wyrwoll, P. J. Mark, T. A. Mori, I. B. Puddey, and B. J. Waddell
Prevention of Programmed Hyperleptinemia and Hypertension by Postnatal Dietary {omega}-3 Fatty Acids
Endocrinology, January 1, 2006; 147(1): 599 - 606.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. Jakobsson, J. A. Jorgensen, and A. Jacobsson
Differential regulation of fatty acid elongation enzymes in brown adipocytes implies a unique role for Elovl3 during increased fatty acid oxidation
Am J Physiol Endocrinol Metab, October 1, 2005; 289(4): E517 - E526.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
N. Draper and P. M Stewart
11{beta}-Hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action
J. Endocrinol., August 1, 2005; 186(2): 251 - 271.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
I. J Bujalska, N. Draper, Z. Michailidou, J. W Tomlinson, P. C White, K. E Chapman, E. A Walker, and P. M Stewart
Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11{beta}-hydroxysteroid dehydrogenase type 1
J. Mol. Endocrinol., June 1, 2005; 34(3): 675 - 684.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
L. M. Watts, V. P. Manchem, T. A. Leedom, A. L. Rivard, R. A. McKay, D. Bao, T. Neroladakis, B. P. Monia, D. M. Bodenmiller, J. X.-C. Cao, et al.
Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression With Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in Diabetic Rodents Without Causing Systemic Glucocorticoid Antagonism
Diabetes, June 1, 2005; 54(6): 1846 - 1853.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. N. Hewitt, E. A. Walker, and P. M. Stewart
Minireview: Hexose-6-Phosphate Dehydrogenase and Redox Control of 11{beta}-Hydroxysteroid Dehydrogenase Type 1 Activity
Endocrinology, June 1, 2005; 146(6): 2539 - 2543.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. R. Daniels, D. K. Arnett, R. H. Eckel, S. S. Gidding, L. L. Hayman, S. Kumanyika, T. N. Robinson, B. J. Scott, S. St. Jeor, and C. L. Williams
Overweight in Children and Adolescents: Pathophysiology, Consequences, Prevention, and Treatment
Circulation, April 19, 2005; 111(15): 1999 - 2012.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
M. Grohmann, M. Sabin, J. Holly, J. Shield, E. Crowne, and C. Stewart
Characterization of differentiated subcutaneous and visceral adipose tissue from children: the influences of TNF-{alpha} and IGF-I
J. Lipid Res., January 1, 2005; 46(1): 93 - 103.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
M. Quinkler, B. Sinha, J. W Tomlinson, I. J Bujalska, P. M Stewart, and W. Arlt
Androgen generation in adipose tissue in women with simple obesity - a site-specific role for 17{beta}-hydroxysteroid dehydrogenase type 5
J. Endocrinol., November 1, 2004; 183(2): 331 - 342.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
J. P. Girod and D. J. Brotman
Does altered glucocorticoid homeostasis increase cardiovascular risk?
Cardiovasc Res, November 1, 2004; 64(2): 217 - 226.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. W. Tomlinson, E. A. Walker, I. J. Bujalska, N. Draper, G. G. Lavery, M. S. Cooper, M. Hewison, and P. M. Stewart
11{beta}-Hydroxysteroid Dehydrogenase Type 1: A Tissue-Specific Regulator of Glucocorticoid Response
Endocr. Rev., October 1, 2004; 25(5): 831 - 866.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. A. Permana, S. Nair, Y.-H. Lee, G. Luczy-Bachman, B. Vozarova de Courten, and P. A. Tataranni
Subcutaneous abdominal preadipocyte differentiation in vitro inversely correlates with central obesity
Am J Physiol Endocrinol Metab, June 1, 2004; 286(6): E958 - E962.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. E. la Fleur, S. F. Akana, S. L. Manalo, and M. F. Dallman
Interaction between Corticosterone and Insulin in Obesity: Regulation of Lard Intake and Fat Stores
Endocrinology, May 1, 2004; 145(5): 2174 - 2185.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. W. Tomlinson, B. Sinha, I. Bujalska, M. Hewison, and P. M. Stewart
Expression of 11{beta}-Hydroxysteroid Dehydrogenase Type 1 in Adipose Tissue Is Not Increased in Human Obesity
J. Clin. Endocrinol. Metab., December 1, 2002; 87(12): 5630 - 5635.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
P. A. Zuk, M. Zhu, P. Ashjian, D. A. De Ugarte, J. I. Huang, H. Mizuno, Z. C. Alfonso, J. K. Fraser, P. Benhaim, and M. H. Hedrick
Human Adipose Tissue Is a Source of Multipotent Stem Cells
Mol. Biol. Cell, December 1, 2002; 13(12): 4279 - 4295.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
O. Paulmyer-Lacroix, S. Boullu, C. Oliver, M.-C. Alessi, and M. Grino
Expression of the mRNA Coding for 11{beta}-Hydroxysteroid Dehydrogenase Type 1 in Adipose Tissue from Obese Patients: An in Situ Hybridization Study
J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2701 - 2705.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C. B. Whorwood, S. J. Donovan, D. Flanagan, D. I.W. Phillips, and C. D. Byrne
Increased Glucocorticoid Receptor Expression in Human Skeletal Muscle Cells May Contribute to the Pathogenesis of the Metabolic Syndrome
Diabetes, April 1, 2002; 51(4): 1066 - 1075.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. G. McTernan, L. A. Anderson, A. J. Anwar, M. C. Eggo, J. Crocker, A. H. Barnett, P. M. Stewart, and S. Kumar
Glucocorticoid Regulation of P450 Aromatase Activity in Human Adipose Tissue: Gender and Site Differences
J. Clin. Endocrinol. Metab., March 1, 2002; 87(3): 1327 - 1336.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. A. Anderson, P. G. McTernan, A. H. Barnett, and S. Kumar
The Effects of Androgens and Estrogens on Preadipocyte Proliferation in Human Adipose Tissue: Influence of Gender and Site
J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 5045 - 5051.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
C. Punyadeera, M-T. van der Merwe, N. J. Crowther, M. Toman, G. P. Schlaphoff, and I. P. Gray
Ethnic differences in lipid metabolism in two groups of obese South African women
J. Lipid Res., May 1, 2001; 42(5): 760 - 767.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. B. Whorwood, S. J. Donovan, P. J. Wood, and D. I. W. Phillips
Regulation of Glucocorticoid Receptor {{alpha}} and {beta} Isoforms and Type I 11{beta}-Hydroxysteroid Dehydrogenase Expression in Human Skeletal Muscle Cells: A Key Role in the Pathogenesis of Insulin Resistance?
J. Clin. Endocrinol. Metab., May 1, 2001; 86(5): 2296 - 2308.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
M. N. Dieudonne, R. Pecquery, M. C. Leneveu, and Y. Giudicelli
Opposite Effects of Androgens and Estrogens on Adipogenesis in Rat Preadipocytes: Evidence for Sex and Site-Related Specificities and Possible Involvement of Insulin-Like Growth Factor 1 Receptor and Peroxisome Proliferator-Activated Receptor {gamma}2
Endocrinology, February 1, 2000; 141(2): 649 - 656.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
I. J. Bujalska, S. Kumar, M. Hewison, and P. M. Stewart
Differentiation of Adipose Stromal Cells: The Roles of Glucocorticoids and 11{beta}-Hydroxysteroid Dehydrogenase
Endocrinology, July 1, 1999; 140(7): 3188 - 3196.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Takami, Z. Y. H. Wong, M. Stebbing, and S. B. Harrap
Linkage analysis of glucocorticoid and beta 2-adrenergic receptor genes with blood pressure and body mass index
Am J Physiol Heart Circ Physiol, April 1, 1999; 276(4): H1379 - H1384.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. N. Dieudonne, R. Pecquery, A. Boumediene, M. C. Leneveu, and Y. Giudicelli
Androgen receptors in human preadipocytes and adipocytes: regional specificities and regulation by sex steroids
Am J Physiol Cell Physiol, June 1, 1998; 274(6): C1645 - C1652.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Lacasa, E. Garcia, B. Agli, and Y. Giudicelli
Control of Rat Preadipocyte Adipose Conversion by Ovarian Status: Regional Specificity and Possible Involvement of the Mitogen-Activated Protein Kinase-Dependent and c-fos Signaling Pathways
Endocrinology, July 1, 1997; 138(7): 2729 - 2734.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. A. Yanovski, S. Z. Yanovski, P. W. Gold, and G. P. Chrousos
Differences in Corticotropin-Releasing Hormone-Stimulated Adrenocorticotropin and Cortisol before and after Weight Loss
J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1874 - 1878.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1987 by The Endocrine Society