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Journal of Clinical Endocrinology & Metabolism Vol. 64, No. 3 628-630
doi:10.1210/jcem-64-3-628
Copyright © 1987 by the Endocrine Society.
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5{alpha}-Reduced Androgens in the Human Fetal Testis*

FREDRICK W. GEORGE, BRUCE R. CARR, JANET F. NOBLE and JEAN D. WILSON

Departments of Cell Biology and Anatomy, University of Texas Health Science Center Dallas, Texas 75235
Departments of Obstetrics and Gynecology and Cecil H. and Ida Green Center for Reproductive Biological Sciences, University of Texas Health Science Center Dallas, Texas 75235
Departments of Internal Medicine, University of Texas Health Science Center Dallas, Texas 75235

Address requests for reprints to: Dr. Jean D. Wilson, Department of Internal Medicine, University of Texas Health Science Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235.

The androgen content was measured in testes from 34 male and in ovaries from 30 female embryos that varied in age from less than 12 to approximately 20 weeks. The 5{alpha}-reduced androgens dihydrotestosterone and 3{alpha}-androstanediol were found in testes at a level of about a 30th of that of testosterone at all ages examined, whereas very little or no testosterone, androstenedione, or either of the 5{alpha}-reduced andfogens were detected in the ovaries. Whether dihydrotestosterone plays a role in the development of the testes is unknown.

* This work was aided by NIH Grants AM-03892 and HD-17814.

Received September 19, 1986.




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Copyright © 1987 by The Endocrine Society