Journal of Clinical Endocrinology & Metabolism, Vol 64, 81-85, Copyright © 1987 by Endocrine Society

ARTICLES

High plasma concentrations of human atrial natriuretic polypeptide in aged men

M Ohashi, N Fujio, H Nawata, K Kato, H Ibayashi, K Kangawa and H Matsuo

To examine the effect of age on the secretion and action of human atrial natriuretic polypeptide (hANP), we compared plasma atrial natriuretic polypeptide and cGMP concentrations in 19 normal young (24- 28 yr old) and 31 elderly (64-91 yr old) men. The mean basal plasma hANP level was 25 +/- 5 (+/- SEM) pg/ml in the young men and 120 +/- 22 pg/ml in the elderly men (P less than 0.01). The molecular size of plasma hANP in an aged man was similar to that of alpha hANP. The responses of plasma hANP and cGMP concentrations to an iv infusion of 500 ml 0.15 M NaCl also was compared. Mean plasma hANP concentrations increased significantly in both groups, and the response in the elderly men was exaggerated compared to that in the young men. However, the increases in plasma cGMP concentrations during NaCl loading were similar in both groups. We conclude that 1) the plasma hANP concentrations in healthy elderly men are higher than those in young men, and 2) the higher plasma hANP concentrations may be a compensatory response to reduced hANP activation of its receptors.

This article has been cited by other articles:

				D. Muller, L. Cortes-Dericks, L. T. Budnik, B. Brunswig-Spickenheier, M. Pancratius, R. C. Speth, A. K. Mukhopadhyay, and R. Middendorff Homologous and Lysophosphatidic Acid-Induced Desensitization of the Atrial Natriuretic Peptide Receptor, Guanylyl Cyclase-A, in MA-10 Leydig Cells Endocrinology, June 1, 2006; 147(6): 2974 - 2985. [Abstract] [Full Text] [PDF]

				P. Meneton, X. Jeunemaitre, H. E. de Wardener, and G. A. Macgregor Links Between Dietary Salt Intake, Renal Salt Handling, Blood Pressure, and Cardiovascular Diseases Physiol Rev, April 1, 2005; 85(2): 679 - 715. [Abstract] [Full Text] [PDF]

				D. Fliser Ren sanus in corpore sano: the myth of the inexorable decline of renal function with senescence Nephrol. Dial. Transplant., March 1, 2005; 20(3): 482 - 485. [Full Text] [PDF]

				E R Greig, T Mathialahan, R P Boot-Handford, and G I Sandle Molecular and functional studies of electrogenic Na+ transport in the distal colon and rectum of young and elderly subjects Gut, November 1, 2003; 52(11): 1607 - 1615. [Abstract] [Full Text] [PDF]

				A. E. Luckey and C. J. Parsa Fluid and Electrolytes in the Aged Arch Surg, October 1, 2003; 138(10): 1055 - 1060. [Abstract] [Full Text] [PDF]

				V. Kirchner, L.E. Silver, and C.A. Kelly Selective serotonin reuptake inhibitors and hyponatraemia: review and proposed mechanisms in the elderly J Psychopharmacol, January 1, 1998; 12(4): 396 - 400. [Abstract] [PDF]

				S. Shigematsu, T. Yamada, T. Aizawa, N. Takasu, and Z. Shimizu Differential Effects of Nifedipine on Plasma Atrial Natriuretic Peptide in Normal Subjects and Hypertensive Patients Angiology, January 1, 1992; 43(1): 40 - 46. [Abstract] [PDF]