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Journal of Clinical Endocrinology & Metabolism Vol. 63, No. 6 1390-1393
doi:10.1210/jcem-63-6-1390
Copyright © 1986 by the Endocrine Society.
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Parathyroid Localization

R. GUTEKUNST, A. VALESKY, B. BORISCH, W. HAFERMANN, E. KIFFNER, E. THIES, U. LÖHRS and P. C. SCRIBA

Departments of Internal Medicine, Medical University Lübeck Lübeck, West Germany
Departments of Surgery, Medical University Lübeck Lubeck, West Germany
Institutes of Anatomy, Medical University Lübeck Lubeck, West Germany
Institutes of Pathology, Medical University Lübeck Lübeck, West Germany

Address requests for reprints to:Dr. R.Gutekunst, Klinik für Innere Medizin, Medical University Lübeck, Ratzeburger Allee 160, 2400 Lubeck, West Germany.

Twenty-nine consecutive patients with suspected primary hyperparathyroidism were examined preoperatively using ultrasound, sonographically guided fine needle aspiration, and aspirate immunostaining for PTH. In 25 patients, localization of enlarged parathyroid glands was successful. In 2 patients, the tumors were located retrosternally and, thus, could not be detected by ultrasound. One patient had a multinodular goiter which impeded localization. In 1 patient with renal osteodystrophy, 2 enlarged parathyroid glands in the neck were not visualized preoperatively. Cytology was not diagnostic, although some cytological features were suggestive of parathyroid cells. Immunostaining of the aspirated smears for PTH, however, correctly diagnosed all preoperatively localized lesions. Ultrasound should be the routine procedure of choice for preoperative localization of abnormal parathyroid glands in primary hyper-parathyroidism. Fine needle aspiration and immunocytochemistry can supply confirmation, if necessary.

Received March 27, 1986.






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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
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Copyright © 1986 by The Endocrine Society