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Department of Physical and Pharmaceutical Chemistry, Tokyo College of Pharmacy, 1432-1Horinouchi,Hachioji, Tokyo 192-03; First Department of Internal Medicine, Toho University School Of Medicine, 5–21–16 Omori Nishi, Ota-ku, Tokyo 143,Japan
Address requests for reprints to: Dr. Shigeo Baba; Tokyo College of Pharmacy, 1432-1 Horinouchi, Hachioji, Tokyo 192-03, Japan.
The pharmacokinetic characteristics of testosterone propionate were studied in normal men after a single im dose of 25 mg testosterone propionate-19,i9,19-d3; Plasma levels of testosterone propionate-19,19,19-d3, its active metabolite testosterone-i9,19,19-d3, and endogenous testosterone were measured by gas chromatography-mass spectrometry. Testosterone propionate-19,19,l9-d3 was gradually transferred from the im injection site to the systemic circulation. The plasma levels of testosterone propionate-19,l9,19-d3 were maintained at 2–4 ng/ ml between 3 and 36 h after administration. Plasma testosterone-i9,19,19-d3 levels were maintained above the physiological testosterone level for 48 h, while plasma levels of endogenous testosterone changed little.
Received May 19, 1986.
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