Journal of Clinical Endocrinology & Metabolism, Vol 63, 815-818, Copyright © 1986 by Endocrine Society

ARTICLES

Plasma levels of atrial natriuretic peptide in primary aldosteronism and essential hypertension

T Yamaji, M Ishibashi, H Sekihara, F Takaku, H Nakaoka and J Fujii

Plasma levels of atrial natriuretic peptide (ANP) were measured in 9 patients with primary aldosteronism and 41 patients with essential hypertension (class I or II by WHO classification) using a specific and sensitive RIA. The mean plasma ANP concentration in patients with primary aldosteronism (mean +/- SEM, 67.1 +/- 10.8 pg/ml; n = 9) was significantly higher than that in healthy normotensive subjects (37.9 +/- 1.4 pg/ml; n = 108) or patients with essential hypertension (38.5 +/- 2.8 pg/ml; n = 41). During treatment with spironolactone, plasma levels of ANP declined in 6 of the 7 patients with primary aldosteronism, but no change occurred in the remaining patient who had cardiac enlargement of unknown etiology. The mean plasma ANP concentration in patients with essential hypertension, on the other hand, was not significantly different from that in normal subjects. These results indicate that plasma ANP levels are elevated in patients with primary aldosteronism, probably due to volume expansion, whereas no abnormality in ANP secretion exists in patients with uncomplicated essential hypertension.

This article has been cited by other articles:

				G. Schreij, P. N. van Es, P. M.H. Schiffers, and P. W. de Leeuw Renal Extraction of Atrial Natriuretic Peptide in Hypertensive Patients With or Without Renal Artery Stenosis Hypertension, June 1, 1996; 27(6): 1254 - 1258. [Abstract] [Full Text]