Journal of Clinical Endocrinology & Metabolism, Vol 63, 1028-1030, Copyright © 1986 by Endocrine Society

ARTICLES

Growth response relationship between growth hormone dose and short term growth in patients with Turner's syndrome

JL Ross, LM Long, M Skerda, F Cassorla, DL Loriaux and GB Cutler Jr

Short stature is a common feature of Turner's syndrome. We studied the dose-response relationship between short term linear growth and GH dose using the lower leg-measuring device. Three doses of GH (0.05, 0.15, and 0.45 U/kg, three times weekly) were given sc for 1-month treatment periods. Lower leg growth rate increased significantly during treatment with the 0.15 and 0.45 U/kg doses [1.8 +/- 0.2 (+/- SEM) and 1.7 +/- 0.3 mm/4 weeks). The higher dose of 0.45 U/kg was no more effective than the 0.15 U/kg dose. Serum somatomedin-C levels increased after treatment with each of the three doses of GH, but did not differ in any of the three dosage groups. We conclude that 0.15 U/kg GH, three times weekly, stimulates short term growth in patients with Turner's syndrome. Longer term studies are required to determine if this increased growth rate is sustained.

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				C. A. Quigley, B. J. Crowe, D. G. Anglin, and J. J. Chipman Growth Hormone and Low Dose Estrogen in Turner Syndrome: Results of a United States Multi-Center Trial to Near-Final Height J. Clin. Endocrinol. Metab., May 1, 2002; 87(5): 2033 - 2041. [Abstract] [Full Text] [PDF]

				J.-C. Carel, L. Mathivon, C. Gendrel, J.-P. Ducret, and J.-L. Chaussain Near Normalization of Final Height with Adapted Doses of Growth Hormone in Turner's Syndrome J. Clin. Endocrinol. Metab., May 1, 1998; 83(5): 1462 - 1466. [Abstract] [Full Text]