help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dahl, K. D.
Right arrow Articles by Hsueh, A. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dahl, K. D.
Right arrow Articles by Hsueh, A. J.

Journal of Clinical Endocrinology & Metabolism, Vol 63, 792-794, Copyright © 1986 by Endocrine Society

ARTICLES

The changing ratio of serum bioactive to immunoreactive follicle- stimulating hormone in normal men following treatment with a potent gonadotropin releasing hormone antagonist

KD Dahl, SN Pavlou, WJ Kovacs and AJ Hsueh

Using a recently developed granulosa cell aromatase bioassay (GAB), we measured serum bioactive follicle-stimulating hormone (bio-FSH) levels in 5 normal men after administration of a potent GnRH antagonist. Although only minimal suppression of immunoreactive FSH (immuno-FSH) was detected during administration of 20 mg of the antagonist, [N-Ac-D- Nal(2)1,D-pCl-Phe2,D-Trp3,D-h(Arg(Et2)6,D-Ala10]GnRH , pronounced inhibition (79 to 89%) of bio-FSH levels occurred. Concomitantly, the ratio of bio- to immuno-FSH levels dramatically decreased within 6 h after antagonist administration. These data reinforce earlier expectations that GnRH antagonists might be potential male contraceptives and provide the first report of changes in circulating bio- to immuno-FSH levels. The GAB assay will facilitate future studies on the biochemical mechanisms by which GnRH antagonists induce changes in the bioactivity of circulating FSH.


This article has been cited by other articles:


Home page
 Hum ReprodHome page
E.V. Velasquez, S. Creus, R.V. Trigo, S.B. Cigorraga, E.H. Pellizzari, H.B. Croxatto, and S. Campo
Pituitary-ovarian axis during lactational amenorrhoea. II. Longitudinal assessment of serum FSH polymorphism before and after recovery of menstrual cycles
Hum. Reprod., April 1, 2006; 21(4): 916 - 923.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. Oberye, B. Mannaerts, J. Huisman, and C. Timmer
Local tolerance, pharmacokinetics, and dynamics of ganirelix (Orgalutran(R)) administration by Medi-Jector(R) compared to conventional needle injections
Hum. Reprod., February 1, 2000; 15(2): 245 - 249.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. D. Veldhuis, A. Iranmanesh, L. M. Demers, and T. Mulligan
Joint Basal and Pulsatile Hypersecretory Mechanisms Drive the Monotropic Follicle-Stimulating Hormone (FSH) Elevation in Healthy Older Men: Concurrent Preservation of the Orderliness of the FSH Release Process: A General Clinical Research Center Study
J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3506 - 3514.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
K. Dahl, T. Bicsak, and A. Hsueh
Naturally occurring antihormones: secretion of FSH antagonists by women treated with a GnRH analog
Science, January 1, 1988; 239(4835): 72 - 74.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1986 by The Endocrine Society