| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Journal of Clinical Endocrinology & Metabolism, Vol 63, 424-432, Copyright © 1986 by Endocrine Society
ARTICLES |
B Dawson-Hughes, D Stern, J Goldman and S Reichlin
To determine the effects of estrogen deficiency and replacement on GH secretion, we measured the 22-h GH secretory pattern and response to 1 h of light exercise in 16 normal postmenopausal women before and after treatment replacement with ethinyl estradiol (20 micrograms/day for 15 days). To determine whether the changes found were due to pituitary sensitization by estrogen, the response to synthetic GH-releasing hormone (GHRH; 1.0 microgram/kg, iv) was measured. To assess the biological effectiveness of GH in estrogen-treated women, somatomedin-C (Sm-C) responses to GHRH were measured. Pre- and postestrogen GH secretion rates, expressed as mean areas circumscribed by plasma GH values, were as follows: 22-h study, 1.4 +/- 0.1 (+/- SEM) vs. 2.0 +/- 0.3 ng/ml X h (P = 0.04; n = 5); during 1 h of exercise, 2.3 +/- 0.4 vs. 3.2 +/- 0.4 ng/ml X h (P = 0.03; n = 16); after GHRH-(1-40), 6.7 +/- 1.7 vs. 8.5 +/- 1.5 ng/ml X h (P = 0.12; n = 16). There also was a modest but significant increase in resting plasma GH (1.5 +/- 0.2 vs. 2.3 +/- 0.5 ng/ml (P = 0.039). Pre- and postestrogen plasma Sm-C concentrations were 0.56 +/- 0.08 and 0.32 +/- 0.03 U/ml, respectively (P = 0.006; n = 16). Thus, estrogen therapy increased spontaneous and exercise-induced GH secretion in postmenopausal women and reduced Sm-C levels. The mechanisms of GH elevation by estrogen may include both central effects and a negative feedback linkage to reduced plasma Sm activity.
This article has been cited by other articles:
 |
|
 |
|
  T. Munzer, C. J. Rosen, S.M. Harman, K. M. Pabst, C. St. Clair, J. D. Sorkin, and M. R. Blackman Effects of GH and/or sex steroids on circulating IGF-I and IGFBPs in healthy, aged women and men Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E1006 - E1013. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J A Kanaley, I Giannopoulou, S Collier, R Ploutz-Snyder, and R Carhart Jr Hormone-replacement therapy use, but not race, impacts the resting and exercise-induced GH response in postmenopausal women Eur. J. Endocrinol., October 1, 2005; 153(4): 527 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Christiansen, S. Fisker, C. H. Gravholt, P. Bennett, B. Svenstrup, M. Andersen, U. Feldt-Rasmussen, J. S. Christiansen, and J. O. L. Jorgensen Discontinuation of estrogen replacement therapy in GH-treated hypopituitary women alters androgen status and IGF-I Eur. J. Endocrinol., May 1, 2005; 152(5): 719 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P A Rooman, L. O. De Beeck, M. Martin, J. van Doorn, S. Mohan, and M. V L Du Caju Ethinylestradiol and testosterone have divergent effects on circulating IGF system components in adolescents with constitutional tall stature Eur. J. Endocrinol., April 1, 2005; 152(4): 597 - 604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Veldhuis, J. N. Roemmich, E. J. Richmond, A. D. Rogol, J. C. Lovejoy, M. Sheffield-Moore, N. Mauras, and C. Y. Bowers Endocrine Control of Body Composition in Infancy, Childhood, and Puberty Endocr. Rev., February 1, 2005; 26(1): 114 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-C. Leung, G. Johannsson, G. M. Leong, and K. K. Y. Ho Estrogen Regulation of Growth Hormone Action Endocr. Rev., October 1, 2004; 25(5): 693 - 721. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Hoffman, C. J. Strasburger, A. Zagar, W. F. Blum, A. Kehely, and M. L. Hartman Efficacy and Tolerability of an Individualized Dosing Regimen for Adult Growth Hormone Replacement Therapy in Comparison with Fixed Body Weight-Based Dosing J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3224 - 3233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Blackman, J. D. Sorkin, T. Munzer, M. F. Bellantoni, J. Busby-Whitehead, T. E. Stevens, J. Jayme, K. G. O'Connor, C. Christmas, J. D. Tobin, et al. Growth Hormone and Sex Steroid Administration in Healthy Aged Women and Men: A Randomized Controlled Trial JAMA, November 13, 2002; 288(18): 2282 - 2292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Veldhuis, W. S. Evans, and C. Y. Bowers Impact of Estradiol Supplementation on Dual Peptidyl Drive of GH Secretion in Postmenopausal Women J. Clin. Endocrinol. Metab., February 1, 2002; 87(2): 859 - 866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Anderson, L. Wideman, J. T. Patrie, A. Weltman, C. Y. Bowers, and J. D. Veldhuis E2 Supplementation Selectively Relieves GH's Autonegative Feedback on GH-Releasing Peptide-2-Stimulated GH Secretion J. Clin. Endocrinol. Metab., December 1, 2001; 86(12): 5904 - 5911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Orrego, M. Russell-Aulet, R. Demott-Friberg, and A. L. Barkan Semiquantification of Hypothalamic GH-Releasing Hormone Output in Women: Evidence for Sexual Dimorphism in the Mechanism of the Somatopause J. Clin. Endocrinol. Metab., November 1, 2001; 86(11): 5485 - 5490. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Asthana, L. D. Baker, S. Craft, F. Z. Stanczyk, R. C. Veith, M. A. Raskind, and S. R. Plymate High-dose estradiol improves cognition for women with AD: Results of a randomized study Neurology, August 28, 2001; 57(4): 605 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Clasey, A. Weltman, J. Patrie, J. Y. Weltman, S. Pezzoli, C. Bouchard, M. O. Thorner, and M. L. Hartman Abdominal Visceral Fat and Fasting Insulin Are Important Predictors of 24-Hour GH Release Independent of Age, Gender, and Other Physiological Factors J. Clin. Endocrinol. Metab., August 1, 2001; 86(8): 3845 - 3852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Oleksik, T. Duong, N. Pliester, G. Asma, C. Popp-Snijders, and P. Lips Effects of the Selective Estrogen Receptor Modulator, Raloxifene, on the Somatotropic Axis and Insulin-Glucose Homeostasis J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2763 - 2768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. YAMASAKI, T. DOUCHI, S. YAMAMOTO, T. OKI, R. KUWAHATA, and Y. NAGATA Body Fat Distribution and Body Composition During GnRH Agonist Therapy Obstet. Gynecol., March 1, 2001; 97(3): 338 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. T. Span, G. F. F. M. Pieters, C. G. J. Sweep, A. R. M. M. Hermus, and A. G. H. Smals Gender Difference in Insulin-Like Growth Factor I Response to Growth Hormone (GH) Treatment in GH-Deficient Adults: Role of Sex Hormone Replacement J. Clin. Endocrinol. Metab., March 1, 2000; 85(3): 1121 - 1125. [Abstract] [Full Text]
|
|
|
|
|
|
G. Van den Berghe, R. C. Baxter, F. Weekers, P. Wouters, C. Y. Bowers, and J. D. Veldhuis A Paradoxical Gender Dissociation within the Growth Hormone/Insulin-Like Growth Factor I Axis during Protracted Critical Illness J. Clin. Endocrinol. Metab., January 1, 2000; 85(1): 183 - 192. [Abstract] [Full Text]
|
|
|
|
|
|
Y. J. H. Janssen, F. Helmerhorst, M. Frölich, and F. Roelfsema A Switch from Oral (2 mg/Day) to Transdermal (50 {micro}g/Day) 17{beta}-Estradiol Therapy Increases Serum Insulin-Like Growth Factor-I Levels in Recombinant Human Growth Hormone (GH)-Substituted Women with GH Deficiency J. Clin. Endocrinol. Metab., January 1, 2000; 85(1): 464 - 467. [Abstract] [Full Text]
|
|
|
|
|
|
D. M. Cook, W. H. Ludlam, and M. B. Cook Route of Estrogen Administration Helps to Determine Growth Hormone (GH) Replacement Dose in GH-Deficient Adults J. Clin. Endocrinol. Metab., November 1, 1999; 84(11): 3956 - 3960. [Abstract] [Full Text]
|
|
|
|
|
|
P. Garnero, Y. Tsouderos, I. Marton, C. Pelissier, C. Varin, and P. D. Delmas Effects of Intranasal 17{beta}-Estradiol on Bone Turnover and Serum Insulin-Like Growth Factor I in Postmenopausal Women J. Clin. Endocrinol. Metab., July 1, 1999; 84(7): 2390 - 2397. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. Shah, W. S. Evans, and J. D. Veldhuis Actions of estrogen on pulsatile, nyctohemeral, and entropic modes of growth hormone secretion Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1999; 276(5): R1351 - R1358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Giustina and J. D. Veldhuis Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human Endocr. Rev., December 1, 1998; 19(6): 717 - 797. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. R. Kraemer, L. G. Johnson, R. Haltom, G. R. Kraemer, H. Gaines, M. Drapcho, T. Gimple, and V. D. Castracane Effects of hormone replacement on growth hormone and prolactin exercise responses in postmenopausal women J Appl Physiol, February 1, 1998; 84(2): 703 - 708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Fryburg, A. Weltman, L. A. Jahn, J. Y. Weltman, E. Samojlik, R. L. Hintz, and J. D. Veldhuis Short-Term Modulation of the Androgen Milieu Alters Pulsatile, But Not Exercise- or Growth Hormone (GH)-Releasing Hormone-Stimulated GH Secretion in Healthy Men: Impact of Gonadal Steroid and GH Secretory Changes on Metabolic Outcomes J. Clin. Endocrinol. Metab., November 1, 1997; 82(11): 3710 - 3719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hornum, D. M. Cooper, J. A. Brasel, A. Bueno, and K. E. Sietsema Exercise-induced changes in circulating growth factors with cyclic variation in plasma estradiol in women J Appl Physiol, June 1, 1997; 82(6): 1946 - 1951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Burman, A. G. Johansson, A. Siegbahn, B. Vessby, and F. A. Karlsson Growth Hormone (GH)-Deficient Men Are More Responsive to GH Replacement Therapy Than Women J. Clin. Endocrinol. Metab., February 1, 1997; 82(2): 550 - 555. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
