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Journal of Clinical Endocrinology & Metabolism, Vol 63, 383-388, Copyright © 1986 by Endocrine Society

ARTICLES

Effect of bromocriptine treatment on the fibrous tissue content of prolactin-secreting and nonfunctioning macroadenomas of the pituitary gland

MM Esiri, JS Bevan, CW Burke and CB Adams

We performed a quantitative study using a point-counting technique at the light microscope level of the fibrous tissue content of PRL- secreting and nonfunctioning pituitary macroadenomas from patients treated or untreated with bromocriptine (BC) before surgery. There was a significant increase in the fibrous tissue content of PRL-secreting, but not nonfunctioning, tumors after BC treatment. The extent of the increase in fibrous tissue in prolactinomas correlated with the duration of treatment with BO.


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