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Enolase Subunits in Patients with Neuroendocrine Tumors^*

Departments of Surgery, Internal Medicine, Fujita-Gakuen Health University School of Medicine Toyoake, Aichi 470-11;
Anatomy, Fujita-Gakuen Health University School of Medicine Toyoake, Aichi 470-11;
Neurosurgery, Fujita-Gakuen Health University School of Medicine Toyoake, Aichi 470-11;
Department of Biochemistry, Institute for Developmental Research Aichi Prefecture Colony, Kasugai,Aichi 480-03;
Department of Neurosurgery, Nagoya University School of Medicine Showa-ku, Nagoya 466, Japan

Address requests for reprints to: Katsumi Iwase, M.D., Department of Surgery Fujita-Gakuen Health University School of Medicine, Toyoake, Aichi 470–11, Japan

Concentrations of the , β, and subunits of enolase in surgically resected tumors and serum obtained from patients with various endocrine tumors were measured by a sensitive enzyme immunoassay system. Tissue concentrations of the subunit were significantly elevated in patients with neuroendocrine tumors concurrent with high concentrations of the subunit in their serum, which fell to normal in 90% of those who underwent tumor resection. Immunohistochemical analysis revealed that considerable amounts of the subunit were contained specifically in these tumors. These results indicate that the subunit of enolase is a useful marker for diagnosing and monitoring patients with neuroendocrine tumors. (J Clin Endocrinol Metab63: 94,1986)

^* This work was supported by a research grant from Fujita-Gakuen.

Received April 22, 1985.

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