This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by HIBBAR, M. D. Articles by ROSENBERG, C. S. Search for Related Content PubMed PubMed Citation Articles by HIBBAR, M. D. Articles by ROSENBERG, C. S.

Insulin Antagonism Is Not a Primary Abnormality of Amyotrophic Lateral Sclerois but Is Related to Disease Severity^*

MICHAEL D. HIBBAR, MAYER B. DAVIDSON and CAROL S. ROSENBERG

Department of Medicine, Cedars-Sinai Medical Center-UCLA Los Angeles, California 90048

Address all correspondence and requests for reprints to: Mayer B. Davidson, M.D., Division of Endocrinology, Room 1735, Cedars-Sinai Medical Center, 8700 BeverlyBoulevard, Los Angeles, California 90048.

Sensitivity to insulin was studied in 13 patients with amyotrophic lateral sclerosis (ALS) and 10 age- and weightmatched normal subjects by performing euglycemic clamp studies at low (1.5 mU/kg-min) and high (10 mU/kg-min) insulin infusion rates. Mean glucose disposal rates were similar in the ALS patients and normal subjects at both the low [4.8 ± 0.6 (± SEM) us. 5.2 ± 0.6 mg/kg-min] and high (9.2 ± 1.3 vs. 9.8 ± 0.5 mg/kg-min) insulin infusion rates, respectively. Binding of [¹²⁵I] iodoinsulin to monocytes was also similar in seven patients with ALS (3.8 ± 1.%/107 cells) and 10 normal subjects (3.9 ± 0.9). However, glucose disposal rates correlated inversely with disease severity in the ALS patients, at both the low (r = —0.76; P ' 0.01) and high (r = —0.83; P ' 0.001) insulin infusion rates. We conclude that insulin antagonism is not a primary abnormality of ALS, butmay be related to the inactivity associated with disease progression. (J ClinEndocrinol Metab 63: 41, 1986)

^* This work was supported by the Amyotrophic Lateral Sclerosis Association of America.

Supported by NIH Training Grant 5T32-AM-07426.

Received August 20, 1985.

This article has been cited by other articles:

				A. L. Peters and M. B. Davidson Effects of Various Enteral Feeding Products on Postprandial Blood Glucose Response in Patients With Type I Diabetes JPEN J Parenter Enteral Nutr, January 1, 1992; 16(1): 69 - 74. [Abstract] [PDF]