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Journal of Clinical Endocrinology & Metabolism, Vol 63, 246-248, Copyright © 1986 by Endocrine Society

ARTICLES

Absence of effect of 24,25-dihydroxyvitamin D3 in primary hyperparathyroidism

JC Netelenbos, H Asscheman, P Lips, WJ Van der Vijgh, MJ Jongen, F Van Ginkel and WH Hackeng

Nineteen patients with primary hyperparathyroidism were treated with 25 micrograms 24,25-dihydroxyvitamin D3 or placebo daily for 3 months according to double-blind cross-over protocol. Serum immunoreactive PTH, total and ionized calcium, urinary calcium excretion, tubular reabsorption of phosphate/glomerular filtrate, and urinary hydroxyproline excretion did not change significantly. Serum 24,25- dihydroxyvitamin D3 levels increased significantly from 1.4 +/- 2.2 (SD) nmol/liter to 38 +/- 11 nmol/liter during the treatment period. Serum 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 levels did not change. We conclude that pharmacological doses of 24,25- dihydroxyvitamin D3 have no suppressive effect on parathyroid function in primary hyperparathyroidism.




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Copyright © 1986 by The Endocrine Society