help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Levesque, L. A.
Right arrow Articles by Seibel, M. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Levesque, L. A.
Right arrow Articles by Seibel, M. M.

Journal of Clinical Endocrinology & Metabolism, Vol 63, 243-245, Copyright © 1986 by Endocrine Society


ARTICLES

The effect of phenytoin and carbamazepine on serum dehydroepiandrosterone sulfate in men and women who have partial seizures with temporal lobe involvement

LA Levesque, AG Herzog and MM Seibel

In a study of 16 men and 55 women with temporal lobe epilepsy (TLE), we found that the serum dehydroepiandrosterone sulfate (DHEA-S) level was significantly lower (P less than 0.05) in patients who were treated with phenytoin (mean +/- SD DHEA-S in men, 685 +/- 429 ng/ml; in women, 580 +/- 289), carbamazepine (women, 779 +/- 529), or a combination of the two drugs (men, 491 +/- 246; women, 474 +/- 284) than in age- and sex-matched untreated patients (men, 2634 +/- 418; women, 2011 +/- 1435) or in normal subjects (men, 2870 +/- 1052; women, 1764 +/- 617). DHEA-S values in the treated groups did not differ from one another. The DHEA-S levels in untreated patients with TLE did not differ significantly from those in normal subjects. TLE alone, therefore, is unlikely to account for the decrease in DHEA-S, and thus, the results suggest that the antiseizure medications are capable of reducing DHEA-S levels. These findings are important because DHEA-S levels are often measured as part of a battery of tests to assess endocrine function in conditions such as polycystic ovarian syndrome, which may be over- represented among women with TLE.


This article has been cited by other articles:


Home page
NeurologyHome page
A. G. Herzog, F. W. Drislane, D. L. Schomer, P. B. Pennell, E. B. Bromfield, B. A. Dworetzky, E. L. Farina, and C. A. Frye
Differential effects of antiepileptic drugs on sexual function and hormones in men with epilepsy
Neurology, October 11, 2005; 65(7): 1016 - 1020.
[Abstract] [Full Text] [PDF]


Home page
NeurologyHome page
P. W. Kaplan
Reproductive health effects and teratogenicity of antiepileptic drugs
Neurology, November 23, 2004; 63(10_suppl_4): S13 - S23.
[Abstract] [Full Text]


Home page
NeurologyHome page
J. I. T. Isojarvi
Reproductive dysfunction in women with epilepsy
Neurology, September 1, 2003; 61(90062): S27 - 34.
[Abstract] [Full Text]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1986 by The Endocrine Society