Journal of Clinical Endocrinology & Metabolism Vol. 63, No. 1 162-166 doi:10.1210/jcem-63-1-162 Copyright © 1986 by the Endocrine Society. Lipocortin Output by Human Endometrium in Vitro*ERLIO GURPIDE, LESZEK MARKIEWICZ, FREDERICK SCHATZ and FUSAO HIRATA
Laboratory of Cell Biology, National Institute of Mental Health Bethesda, Maryland 20205 Address requests for reprints to: Dr. Erlid Gurpide, Department of ObGyn and ReproductiveScience, Mount Sinai School of Medicine, One Gustave Levy Place, New York, New York 10029.
Lipocortin was found to be secreted by human endometrium incubated for 1–2 days under organ culture conditions. Levels of lipocortin in the culture medium, measured by RIA, were increased by dexamethasone (10-8–10-6 M) and decreasedby progesterone (10-8-l0-6 M). Both steroids, however, decreased prostaglandin F2
* This work was supported by Grant HD-07197, awardedby the NICHHD. Received September 12, 1985.
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