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Lipocortin Output by Human Endometrium in Vitro^*

Laboratory of Cell Biology, National Institute of Mental Health Bethesda, Maryland 20205
Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine New York 10029

Address requests for reprints to: Dr. Erlid Gurpide, Department of ObGyn and ReproductiveScience, Mount Sinai School of Medicine, One Gustave Levy Place, New York, New York 10029.

Lipocortin was found to be secreted by human endometrium incubated for 1–2 days under organ culture conditions. Levels of lipocortin in the culture medium, measured by RIA, were increased by dexamethasone (10^-8–10^-6 M) and decreasedby progesterone (10^-8-l0^-6 M). Both steroids, however, decreased prostaglandin F₂ (PGF₂) output, also estimated by RIA. These results suggest that lipocortin does not mediate the inhibition of PGF₂ production evoked by progesterone. Dexamethasone may inhibit PGF₂ production by mechanisms involved in the inhibition by progesterone in addition to those mediated by an elevation in thelevels of lipocortin, a phospholipase inhibitor.

^* This work was supported by Grant HD-07197, awardedby the NICHHD.

Received September 12, 1985.