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Journal of Clinical Endocrinology & Metabolism, Vol 63, 162-166, Copyright © 1986 by Endocrine Society

ARTICLES

Lipocortin output by human endometrium in vitro

E Gurpide, L Markiewicz, F Schatz and F Hirata

Lipocortin was found to be secreted by human endometrium incubated for 1-2 days under organ culture conditions. Levels of lipocortin in the culture medium, measured by RIA, were increased by dexamethasone (10(- 8)-10(-6) M) and decreased by progesterone (10(-8)-10(-6) M). Both steroids, however, decreased prostaglandin F2 alpha (PGF2 alpha) output, also estimated by RIA. These results suggest that lipocortin does not mediate the inhibition of PGF2 alpha production evoked by progesterone. Dexamethasone may inhibit PGF2 alpha production by mechanisms involved in the inhibition by progesterone in addition to those mediated by an elevation in the levels of lipocortin, a phospholipase inhibitor.




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Copyright © 1986 by The Endocrine Society