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Department of Medicine, Michael Reese Hospital and Medical Center, University of Chicago Chicago, Illinois 60616
Address all correspondence and requests for reprints to: Dr. Arthur B. Schneider, Division of Endocrinology and Metabolism, Michael Reese Hospital and Medical Center, Lake Shore Drive at 31st Street, Chicago, Illinois 60616.
In 2561 patients who received conventional external radiation treatment before age 15 yr for benign conditions of the head, neck, and upper thoracic area, we found an increase in the number of salivary gland tumors and benign neural tumors of the head and neck area. To determine whether patients who developed these relatively uncommon tumors were more susceptible to the long term effects of radiation, we analyzed how frequently these patients also developed benign and malignant thyroid neoplasms. Compared to the remainder of the irradiated population, the patients with salivary and neural tumors had an increased frequency of thyroid disease (19.4% us. 11.2% for thyroid cancer and 52.4% us. 39.9% for all thyroid nodules). Various risk factors were studied to determine whether they we’e related to the eventual occurrence of thyroid disease. Higher doses, being female, and lower ages at time of treatment were associated with increased risk. However, these factors did not fully explain the differences in the frequency of coexisting tumors, suggesting that additional factors, such as radiation sensitivity, may account for the increased risk.
* This work was supported in part by NCI grant CA-21518.
Received December 30, 1985.
This article has been cited by other articles:
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  A. B. Schneider, E. Ron, J. Lubin, M. Stovall, E. Shore-Freedman, J. Tolentino, and B. J. Collins Acoustic neuromas following childhood radiation treatment for benign conditions of the head and neck Neuro-oncol, February 1, 2008; 10(1): 73 - 78. [Abstract] [Full Text] [PDF]
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 D. Mihailescu, E. Shore-Freedman, S. Mukani, J. Lubin, E. Ron, and A. B. Schneider Multiple Neoplasms in an Irradiated Cohort: Pattern of Occurrence and Relationship to Thyroid Cancer Outcome J. Clin. Endocrinol. Metab., July 1, 2002; 87(7): 3236 - 3241. [Abstract] [Full Text] [PDF]
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 L. Sznajder, C. Abrahams, D. M. Parry, T. C. Gierlowski, E. Shore-Freedman, and A. B. Schneider Multiple Schwannomas and Meningiomas Associated With Irradiation in Childhood Arch Intern Med, September 9, 1996; 156(16): 1873 - 1878. [Abstract] [PDF]
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 J. Cohen, T. C. Gierlowski, and A. B. Schneider A Prospective Study of Hyperparathyroidism in Individuals Exposed to Radiation in Childhood JAMA, August 1, 1990; 264(5): 581 - 584. [Abstract] [PDF]
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S. Lio, W. Arcese, G. Papa, and M. D'Armiento Thyroid and Pituitary Function Following Allogeneic Bone Marrow Transplantation Arch Intern Med, May 1, 1988; 148(5): 1066 - 1071. [Abstract] [PDF]
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 R. STOCKWELL and F. DAVIDOFF Radiation-Induced Thyroid Carcinoma Ann Intern Med, April 1, 1987; 106(4): 637 - 638. [Abstract] [PDF]
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A. B. SCHNEIDER, W. RECANT, S. M. PINSKY, U. Y. RYO, C. BEKERMAN, and E. SHORE-FREEDMAN Radiation-Induced Thyroid Carcinoma: Clinical Course and Results of Therapy in 296 Patients Ann Intern Med, September 1, 1986; 105(3): 405 - 412. [Abstract] [PDF]
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