help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fisher, E. C.
Right arrow Articles by Evans, W. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fisher, E. C.
Right arrow Articles by Evans, W. J.

Journal of Clinical Endocrinology & Metabolism, Vol 62, 1232-1236, Copyright © 1986 by Endocrine Society

ARTICLES

Bone mineral content and levels of gonadotropins and estrogens in amenorrheic running women

EC Fisher, ME Nelson, WR Frontera, RN Turksoy and WJ Evans

Serum gonadotropin and estrogen levels and their relationship to bone mineral content in exercise-related amenorrhea were studied in 11 amenorrheic women and 24 eumenorrheic women, all of whom were runners. Serum estradiol, LH, FSH, estrone, and testosterone were measured in serial blood samples obtained at 15-min intervals for 4 h. The amenorrheic women had lower estradiol, LH, FSH; and estrone levels as well as a higher estrone-estradiol ratio than did the eumenorrheic women. There was no difference in testosterone levels. The amenorrheic women had lower LH pulse amplitudes, whereas no differences were found in FSH pulse amplitudes. LH and FSH pulse frequencies did not differ between the two groups. Bone mineral content of the lumbar spine was lower in amenorrheic women and was positively correlated with estradiol levels in all women. There was no difference in bone mineral content of the radius. These data suggest that, in exercise-related amenorrhea, low serum LH, FSH, and estrogen levels reflect an alteration in the hypothalamic control of gonadotropin release. Reduced circulating estrogen levels in amenorrheic running women may be a cause of low mineral content of the spine.


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
K. K. Miller, E. A. Lawson, V. Mathur, T. L. Wexler, E. Meenaghan, M. Misra, D. B. Herzog, and A. Klibanski
Androgens in Women with Anorexia Nervosa and Normal-Weight Women with Hypothalamic Amenorrhea
J. Clin. Endocrinol. Metab., April 1, 2007; 92(4): 1334 - 1339.
[Abstract] [Full Text] [PDF]

Home page
 Am J Sports MedHome page
L. A. J. L. M. Braam, M. H. J. Knapen, P. Geusens, F. Brouns, and C. Vermeer
Factors Affecting Bone Loss in Female Endurance Athletes: A Two-Year Follow-Up Study
Am. J. Sports Med., November 1, 2003; 31(6): 889 - 895.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. J. De Souza, B. E. Miller, A. A. Luciano, S. Stier, S. Ulreich, and J. Weigert
Ovulation and Spine Bone Mineral Density--Author's Responsef
J. Clin. Endocrinol. Metab., October 1, 1998; 83(10): 3758 - 3758.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1986 by The Endocrine Society