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Journal of Clinical Endocrinology & Metabolism, Vol 62, 1101-1109, Copyright © 1986 by Endocrine Society

ARTICLES

Interferon-gamma induces the expression of HLA-A,B,C but not HLA-DR on human pancreatic beta-cells

IL Campbell, K Bizilj, PG Colman, BE Tuch and LC Harrison

We examined the effect of interferon-gamma (IFN gamma) on expression of the major histocompatibility proteins on cultured human islet cells isolated from adult and fetal pancreas and from an insulinoma. While the pancreatic beta-cells from different sources varied in their responses to IFN gamma, in all instances the expression of HLA-A,B,C protein was increased. Pancreatic beta-cells did not express HLA-DR protein, before or after culture of the islets in IFN gamma, although HLA-DR protein expression was induced on some non-beta-cells. These findings are at variance with those reported with thyroid follicular cells, in which IFN gamma induced expression of HLA-DR. We, therefore, conclude that the interaction between the immune and the endocrine systems may be endocrine cell specific. The up-regulation of HLA-A,B,C protein on beta-cells by IFN gamma provides a mechanism for enhanced targetting to the beta-cells of autoreactive cytotoxic T-lymphocytes and, hence, for amplifying beta-cell destruction.


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D. Pavlovic, M. Van De Winkel, B. Van der Auwera, M.-C. Chen, F. Schuit, L. Bouwens, and D. Pipeleers
Effect of Interferon-{gamma} and Glucose on Major Histocompatibility Complex Class I and Class II Expression by Pancreatic {beta}- and Non-{beta}-Cells
J. Clin. Endocrinol. Metab., July 1, 1997; 82(7): 2329 - 2336.
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