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Pituitary Stimulation by Combined Administration of Four Hypothalamic Releasing Hormones in Normal Men and Patients^*

Centre de Meédecine Nucleéaire, Hoôpital Neuro-Cardiologique Lyon, France

Address requests for reprints to: Dr. R. Cohen, Centre de Medeécine Nucleéaire, Service de Radiopharmacie et Radioanalyse, 59 boulevard Pinel, Lyon Cedex 03 69394, France.

Ten normal young men (22–28 yr of age), within 10% of their ideal body weight, were given the four releasing hormones (TRH, 200 µg; GnRH, 100 µg; ovine corticotropinreleasing hormone, 50 µg; GH-releasing hormone, 80 µg) iv on separate days and then in combination on the same day. Plasma TSH, PRL, FSH, LH, cortisol, ACTH, and GH were measured by RIA in samples collected from 20 min before to 120 min after injection. There were no significant differences in responses to the separate and combined tests for FSH, LH, cortisol, ACTH, and GH.The plasma TSH (0.001 < P < 0.01) and PRL (P < 0.001) responses were significantly higher after the combined test. The tolerance was identical to that of TRH alone. In eight patients studied after pituitary surgery, combined administration provided results comparable to those obtained after separate administration of TRH, GnRH, and insulin.

^* This work was supported by INSERM Grant 83-4015 and SANOFI.

Received September 9, 1985.