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Effect of Insulin on Glucose Uptake and Metabolism in the Human Placenta

Uniuersité Pierre et Marie Curie Biologiede la Reproduction 75230 Paris
Inserm U 166, Maternité Baudelocque 75014 Paris, France

Address requests for reprints to: Dr. S. Hauguel, Université Pierre et Marie Curie, Biologie de la Reproduction, 75230 Paris, France.

The effect of insulin on glucose uptake, transfer, and metabolism wasinvestigated in' the human placenta perfused in vitro. Insulin concentrations in maternal perfusion medium were varied from 0–1200 µU/ml, whereas the glucose concentration was kept constant in maternal and fetal perfusion media. Despite significant uptake of insulin by the perfused placenta, neither glucose uptake and transfer nor lactate release were significantly modified during a 1-h insulin perfusion. The MCR of insulin by the placenta was 0.29 ± 0.03 (±SEM) ml/min·g at physiological insulin levels. These data suggest that placental glucose transport and metabolism are insensitive to maternal plasma insulin variations and that the low clearance rate of insulin by the placenta is not a major determinant of maternal insulin adjustments during pregnancy. (J Clin Endo crinol Metab 62:803,1986)

Received July 29, 1985.

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