This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by WEIDMANN, P. Articles by BACHMANN, C. Search for Related Content PubMed PubMed Citation Articles by WEIDMANN, P. Articles by BACHMANN, C.

Plasma Levels and Cardiovascular, Endocrine, and Excretory Effects of Atrial Natriuretic Peptide during Different Sodium Intakes in Man^*

Medizinische Poliklinik and the Department of Clinical Chemistry, University of Berne Berne, Switzerland Department of Pharmacology, University of Heidelberg Heidelberg, West Germany

Address all correspondence and requests for reprints to: Peter Weidmann,M.D., Medizinische Universitaets-Poliklinik, Freiburgstrasse 3,3010 Berne, Switzerland.

Endogenous plasma concentrations of human atrial natriuretic peptide (hANP) as well as effects of synthetic hANP on some cardiovascular, endocrine, and renal excretory parameters were investigated in 10 normal subjects during sodium (Na⁺) intakes of 17, 140, and 310 mmol/day, respectively. Plasma hANP was slightly but not significantly higher after 5 days of normal or high sodium intake than after 5 days of low sodium intake [54 ± 13, 46 ± 8, and 37 ± 5 (mean ± SEM) pg/ml, respectively]. hANP infused at 0.1µg/kg-min during all Na⁺ intakes produced a similar fall in diastolic blood pressure (P < 0.001) and rise in heart rate (P < 0.001), a comparable percent increase in plasma norepinephrine (P < 0.001), and a reduction in plasma cortisol and aldosterone (P < 0.01-0.001) despite raised renin activity (P < 0.05-0.001) and unchanged plasma electrolytes. hANP-induced plasma volume contraction, diuresis, and natriuresis were greater during high than low Na⁺ intake (P < 0.01-0.001). Therefore, in normal man different Na⁺ intakes are accompanied by marked modifications in renal excretory responsiveness to hANP. Regardless of sodium intake, hANP can promote BP reduction and hemoconcentration, elicit reflex (?) sympathetic activation, and depress basal circulating aldosterone and cortisol levels in the face of an activated renin system.

^* This work was supported in part by the Swiss National Foundation and a research grant from the Ciba-Geigy Corp. (Basel, Switzerland).

Received August 9, 1985.

This article has been cited by other articles:

				M. Schmitt, A. Qasem, C. McEniery, I. B. Wilkinson, V. Tatarinoff, K. Noble, J. Klemes, N. Payne, M. P. Frenneaux, J. Cockcroft, et al. Role of natriuretic peptides in regulation of conduit artery distensibility Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1167 - H1171. [Abstract] [Full Text] [PDF]

				L. G. MELO, M. E. STEINHELPER, S. C. PANG, Y. TSE, and U. ACKERMANN ANP in regulation of arterial pressure and fluid-electrolyte balance: lessons from genetic mouse models Physiol Genomics, June 29, 2000; 3(1): 45 - 58. [Abstract] [Full Text] [PDF]

				L. G. Melo, A. T. Veress, C. K. Chong, U. Ackermann, and H. Sonnenberg Salt-sensitive hypertension in ANP knockout mice is prevented by AT1 receptor antagonist losartan Am J Physiol Regulatory Integrative Comp Physiol, September 1, 1999; 277(3): R624 - R630. [Abstract] [Full Text] [PDF]

				A. Jansson and K. Dahlborn Effects of feeding frequency and voluntary salt intake on fluid and electrolyte regulation in athletic horses J Appl Physiol, May 1, 1999; 86(5): 1610 - 1616. [Abstract] [Full Text] [PDF]

				L. G. Melo, A. T. Veress, C. K. Chong, S. C. Pang, T. G. Flynn, and H. Sonnenberg Salt-sensitive hypertension in ANP knockout mice: potential role of abnormal plasma renin activity Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1998; 274(1): R255 - R261. [Abstract] [Full Text] [PDF]

				R. Gasser, O. Luha, J. Dusleag, B. Eber, R. Rotman, W. Klein, and G.R. Fueger Observations on Plasma ANP Levels During Short-Term Transient Myocardial Ischemia Produced by PTCA in Patients with LAD Stenosis Angiology, April 1, 1993; 44(4): 278 - 288. [Abstract] [PDF]

				R. L. Cosby, A. M. Sophocles, J. A. Durr, C. L. Perrinjaquet, B. Yee, and R. W. Schrier Elevated Plasma Atrial Natriuretic Factor and Vasopressin in High-Altitude Pulmonary Edema Ann Intern Med, November 15, 1988; 109(10): 796 - 799. [Abstract] [PDF]