help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nagamani, M.
Right arrow Articles by Van Dinh, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nagamani, M.
Right arrow Articles by Van Dinh, T.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*ESTRADIOL
*ESTRONE
*TESTOSTERONE
Medline Plus Health Information
*Menopause
*Uterine Cancer

Journal of Clinical Endocrinology & Metabolism, Vol 62, 508-512, Copyright © 1986 by Endocrine Society

ARTICLES

Ovarian steroid secretion in postmenopausal women with and without endometrial cancer

M Nagamani, EV Hannigan, EA Dillard Jr and T Van Dinh

The concentrations of testosterone (T), androstenedione (A), estradiol (E2), and estrone (E1) were measured in peripheral and ovarian venous serum obtained at the time of bilateral oophorectomy from 15 postmenopausal women with endometrial cancer and 9 without cancer. The cancer and noncancer (control) patients were matched for age, weight, and years since menopause. In women with endometrial cancer, significantly higher ovarian than peripheral venous concentrations were found for all hormones measured [T, 3781 +/- 1255 (+/- SE) vs. 213 +/- 43 pg/ml (P less than 0.01); A, 5352 +/- 1845 vs. 1299 +/- 187 pg/ml (P less than 0.04); E2, 52 +/- 11 vs. 23 +/- 3 pg/ml (P less than 0.02); E1, 81 +/- 12 vs. 32 +/- 2 pg/ml (P less than 0.001)], but in the control patients, only the concentration of T was significantly higher (623 +/- 108 vs. 156 +/- 21 pg/ml; P less than 0.001). Ovarian venous concentrations of T and A were significantly higher in thin women with cancer than in obese women with cancer. These results suggest that the ovaries of postmenopausal women with endometrial cancer secrete significantly more T and A than do the ovaries of women without cancer, while secreting only minimal amounts of E2 and E1. This increase in ovarian steroid secretion might play a role in the pathogenesis of endometrial cancer.


This article has been cited by other articles:


Home page
 Endocr Relat CancerHome page
M. Matsumoto, Y. Yamaguchi, Y. Seino, A. Hatakeyama, H. Takei, H. Niikura, K. Ito, T. Suzuki, H. Sasano, N. Yaegashi, et al.
Estrogen signaling ability in human endometrial cancer through the cancer-stromal interaction
Endocr. Relat. Cancer, June 1, 2008; 15(2): 451 - 463.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. H. Fogle, F. Z. Stanczyk, X. Zhang, and R. J. Paulson
Ovarian Androgen Production in Postmenopausal Women
J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3040 - 3043.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Segawa, M. Shozu, K. Murakami, T. Kasai, K. Shinohara, K. Nomura, S. Ohno, and M. Inoue
Aromatase Expression in Stromal Cells of Endometrioid Endometrial Cancer Correlates with Poor Survival
Clin. Cancer Res., March 15, 2005; 11(6): 2188 - 2194.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
M. Nagamani and R. J. Urban
Expression of Messenger Ribonucleic Acid Encoding Steroidogenic Enzymes in Postmenopausal Ovaries
Reproductive Sciences, January 1, 2003; 10(1): 37 - 40.
[Abstract] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
R. Kaaks, A. Lukanova, and M. S. Kurzer
Obesity, Endogenous Hormones, and Endometrial Cancer Risk: A Synthetic Review
Cancer Epidemiol. Biomarkers Prev., December 1, 2002; 11(12): 1531 - 1543.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
A. AKHMEDKHANOV, A. ZELENIUCH-JACQUOTTE, and P. TONIOLO
Role of Exogenous and Endogenous Hormones in Endometrial Cancer: Review of the Evidence and Research Perspectives
Ann. N.Y. Acad. Sci., September 1, 2001; 943(1): 296 - 315.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1986 by The Endocrine Society