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Serum Levels of Vitamin D Metabolites and Testosterone in Male Puberty

Department of Clinical Chemistry, Glostrup Hospital, Unversity of Copenhagen Copenhagen, Denmark

Address requests for reprints to: Dr. S. Krabbe, Department of Paediatrics, Rigshospitalet, University of Copenhagen, Copenhagen DK-2100, Denmark.

We determined the serum concentrations of 25–hydroxyvitamin D, 1,25–dihydroxyitamin D [1,25–(OH)₂D],24,25-(OH)₂D, and 25,26-(OH)₂D every third month in a 2-yr longitudinal study of 20 normal pubertal boys. Seasonal fluctuations and highly significant correlations with the hours of sunshine were found for 25–hydroxyvitamin D, 24,25-(OH)₂D and 25,26-(OH)₂D, whereas the serum concentrations of 1,25-(OH)₂D were not related to sunshine duration. The boys were grouped according to the time at which the maximal increase in serum testosterone occurred, and the serum vitamin D metabolite levels were examined in relation to this point. No significant changes in the serum levels of the vitamin D metabolites were found. When compiling the data according to clinical evaluation of puberty estimated by pubic hair stages (PH₁ to PH₄), no significant changes in the serum levels of vitamin D metabolites were found. The present data indicate that the marked increase in serum testosterone in male puberty has no significant influence on circulating vitamin D metabolite levels.

Received October 9, 1984.