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Journal of Clinical Endocrinology & Metabolism, Vol 61, 1018-1022, Copyright © 1985 by Endocrine Society

ARTICLES

Dermorphin reduces the metyrapone-evoked release of adrenocorticotropin, beta-endorphin, and beta-lipotropin in man

EC Degli Uberti, F Petraglia, G Trasforini, S Salvadori, A Margutti, M Bianconi, V Teodori, F Facchinetti, R Tomatis and AR Genazzani

The aim of this study was to investigate further the influence of dermorphin (D), a new potent opioid peptide (H-Tyr-D-Ala-Phe-Gly-Tyr- Pro-Ser-NH2), on the functional activity of the pituitary- adrenocortical system in man. Six normal men were treated with oral metyrapone to stimulate the secretion of ACTH, beta-lipotropin, and beta-endorphin. In these subjects, significant suppression of metyrapone-evoked release of ACTH and related peptides occurred during D infusion (5.5 micrograms/kg X min for 30 min) compared with that during saline infusion. These results indicate that D can induce a significant decline in plasma levels of ACTH, beta-lipotropin, and beta- endorphin, the major circulating peptides from the C-terminal part of proopiocortin, and suggest that opioid peptides may be involved in the control of the functional activity of pituitary-adrenocortical activity in man.




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