Journal of Clinical Endocrinology & Metabolism, Vol 61, 993-996, Copyright © 1985 by Endocrine Society

ARTICLES

Sex hormone-binding globulin changes during the menstrual cycle

SR Plymate, DE Moore, CY Cheng, CW Bardin, MB Southworth and MJ Levinski

Although sex hormone-binding globulin (SHBG) production is stimulated by estrogen, no change in SHBG has been demonstrated during the menstrual cycle. To further study possible cyclic changes in serum SHBG, 12 women with a normal menstrual and fertility history had daily SHBG measurements during a menstrual cycle. SHBG was measured by dextran-coated charcoal saturation analysis and RIA. Serum LH was measured by mouse Leydig cell bioassay and RIA, and FSH, estradiol (E2), and progesterone were determined by RIA. In 10 women, a significant increase in mean SHBG by both methods occurred during the luteal phase of the cycle, immediately after the preovulatory increase in serum E2 (P less than 0.001). Two women had no SHBG increase; although each had a significant rise in serum E2 before the LH surge, luteal phase E2 levels were similar to those in the early follicular phase. In one of these women, a rise in SHBG was demonstrated by RIA. This study demonstrates that SHBG changes during the menstrual cycle in association with E2 changes, and it appears to be a marker for the endogenous estrogen changes that occur in normal ovulating women.

This article has been cited by other articles:

				J. J. Puder, B. Muller, and U. Keller Letter re: The Biological Variation of Testosterone and Sex Hormone-Binding Globulin (SHBG) in Polycystic Ovarian Syndrome: Implications for SHBG as a Surrogate Marker of Insulin Resistance J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 4419 - 4420. [Full Text] [PDF]

				R. M. Lovering and W. A. Romani Effect of testosterone on the female anterior cruciate ligament Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R15 - R22. [Abstract] [Full Text] [PDF]

				C. A. Blum, B. Muller, P. Huber, M. Kraenzlin, C. Schindler, C. De Geyter, U. Keller, and J. J. Puder Low-Grade Inflammation and Estimates of Insulin Resistance during the Menstrual Cycle in Lean and Overweight Women J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3230 - 3235. [Abstract] [Full Text] [PDF]

				W.S. Sun, R. Misao, S. Iwagaki, J. Fujimoto, and T. Tamaya Coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases, Axl and Sky, in human uterine endometrium and ovarian endometriosis Mol. Hum. Reprod., June 1, 2002; 8(6): 552 - 558. [Abstract] [Full Text] [PDF]

				G. A. Kaltsas, J. J. Mukherjee, P. J. Jenkins, M. A. Satta, N. Islam, J. P. Monson, G. M. Besser, and A. B. Grossman Menstrual Irregularity in Women with Acromegaly J. Clin. Endocrinol. Metab., August 1, 1999; 84(8): 2731 - 2735. [Abstract] [Full Text]

				Y. Zhang, D. P. Kiel, B. E. Kreger, L. A. Cupples, R. C. Ellison, J. F. Dorgan, A. Schatzkin, D. Levy, and D. T. Felson Bone Mass and the Risk of Breast Cancer among Postmenopausal Women N. Engl. J. Med., February 27, 1997; 336(9): 611 - 617. [Abstract] [Full Text] [PDF]