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Ethanol Decreases Glucose Utilization In Healthy Man^*

Third Department of Medicine, Helsinki University Central Hospital 00290 Helsinki, Finland

Address correspondence and requests for reprints to: Hannele Yki-Jarvinen, MD, Third Department of Medicine, Haartmaninkatu 4, 00290 Helsinki, Finland.

The effect of ethanol on glucose utilization during hyperinsulinemia was studied by the euglycemic clamp technique. Normal subjects were given 1 g ethanol/kg body weight for 210 min (oral priming dose of 0.67 g/kg followed by iv infusion of 0.33 g/kg) or 0.9% saline. Insulin infusion, started 90 min after the beginning of ethanol administration, resulted i n a mean plasma insulin concentration of 87 ± 5 (SEM) mU%liter. Plasma glucose was maintained at 5.2 mmol%liter. The rate of glucose metabolism was 23% lower during ethanol (7.1 ± 0.1 mg%kg-min) than during the control (9.0 ± 0.8 mg%kg-min) experiment (P < 0.001). During hyperinsulinemia blood lactate concentrations rose in the control study but this change was abolished by ethanol. The insulin-induced fall of serum triglyc-eride levels was also inhibited by ethanol. It is concluded that acute intake of alcohol in moderate doses induces insulin resistance.

^* This research was supported by grants from the Finnish State Research Council (Academy of Finland), and the Nordisk Insulinfond Gentofte, Denmark).

Received January 6, 1985.

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