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Journal of Clinical Endocrinology & Metabolism, Vol 60, 1226-1230, Copyright © 1985 by Endocrine Society

ARTICLES

Alteration of erythrocyte membrane lipid fluidity in human obesity

F Beguinot, D Tramontano, C Duilio, S Formisano, L Beguinot, P Mattioli, M Mancini and SM Aloj

The lipophilic probe 1,6-diphenyl-1,3,5-hexatriene was incorporated into erythrocyte ghosts of either normal or obese humans, and the polarization of fluorescence was measured between 0 and 40 C. The membrane lipid fluidity, evaluated by fluorescence polarization, was consistently higher in the ghosts from obese subjects. A strong correlation was found between increased 1,6-diphenyl-1,3,5-hexatriene fluorescence polarization and excess body weight. Measurements of cholesterol and phospholipids indicated increased cholesterol and decreased phospholipids in erythrocyte ghosts from obese subjects. These data suggest that alterations in lipid composition in erythrocytes of obese subjects are responsible for abnormal physical properties of plasma membranes, which, in turn, may cause altered enzymatic activities.


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 ANGIOLOGYHome page
Y. Levy, N. Elias, U. Cogan, and D. Yeshurun
Abnormal Erythrocyte Rheology in Patients with Morbid Obesity
Angiology, September 1, 1993; 44(9): 713 - 717.
[Abstract] [PDF]


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