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*Substance via MeSH
Medline Plus Health Information
*Cushing's Syndrome
*Thyroid Cancer

Journal of Clinical Endocrinology & Metabolism, Vol 60, 496-500, Copyright © 1985 by Endocrine Society

ARTICLES

Cushing's syndrome due to ectopic production of corticotropin-releasing factor

JL Belsky, B Cuello, LW Swanson, DM Simmons, RM Jarrett and F Braza

A patient with Cushing's syndrome is described who had a metastatic medullary carcinoma of the thyroid which contained corticotropin- releasing factor. ACTH was found by an immunohistochemical method in the patient's pituitary, but not in the thyroid tumor. This is the second report demonstrating corticotropin-releasing factor in tumor tissue in this syndrome. Wider use of immunohistological methods can help distinguish this variety from other tumors associated with the ectopic ACTH syndrome when bioassays are not available.


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