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Journal of Clinical Endocrinology & Metabolism, Vol 60, 399-401, Copyright © 1985 by Endocrine Society

ARTICLES

Immunologic identification of both plasma and human renal inactive renin as prorenin

J Bouhnik, JA Fehrentz, FX Galen, R Seyer, G Evin, B Castro, J Menard and P Corvol

Antibodies were raised against a synthetic tetradecapeptide which is a component of the non-renin portion (prosegment) of human renin precursor. Inactive renin from human kidney and plasma strongly adsorbed to a gel coupled to immunoglobulins purified from such an antiserum. These results suggest that renal and circulating inactive human renins contain in their structure the prosegment of prorenin.


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