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Journal of Clinical Endocrinology & Metabolism Vol. 60, No. 2 399-401
doi:10.1210/jcem-60-2-399
Copyright © 1985 by the Endocrine Society.
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IMMUNOLOGIC IDENTIFICATION OF BOTH PLASMA AND HUMAN RENAL INACTIVE RENIN AS PRORENIN

J. BOUHNIK1, J.A. FEHRENTZ2, F.X. GALEN3, R. SEYER2, G. EVIN1, B. CASTRO2, J. MENARD1 and P. CORVOL1

1 INSERM U 36, 17 rue du Fer-3-Moulin 75005 Paris - FRANCE
2 Centre CNRS-INSERM de Pharmacologie Endocrinologie, rue de la Cardonille 34033 Montpellier - FRANCE
3 UER de M6decine et de Pharmacie - Laboratoire de Physiologie - 2 rue du Dr Marchand - 87032 Limoges - FRANCE

Antibodies were raised against a synthetic tetradecapeptide which is a component of the non-renin portion (prosegraent) of human renin precursor. Inactive renin from human kidney and plasma strongly adsorbed to a gel coupled to iramunoglobulins purified from such an antiserum. These results suggest that renal and circulating inactive human renins contain in their structure the prosegment of prorenin.

Received October 24, 1984.




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