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Resolution of Acromegaly, Amenorrhea-Galactorrhea Syndrome, and Hypergastrinemia after Resection of Jejunal Carcinoid

Euclid Clinic Foundation and Euclid General Hospital Euclid, Ohio 44119

Address requests for reprints to: Michael Spero, M.D., Euclid Clinic Foundation, 18599 Lake Shore Boulevard, Euclid, Ohio 44119.

A young woman presented with acromegaly and amenorrhea-galactorrhea with hypersomatotropinemia and hyperprolactinemia. In addition, she had hypergastrinemia with abnormal secretory dynamics and evidence of a large pituitary tumor with suprasellar extension and erosion of the floor of the sella turcica. Evaluation of secretory diarrhea revealed a large abdominal tumor, which on removal was found to be a carcinoid of the jejunum. Postoperatively, the acromegaly, amenorrheagalactorrhea, and hypergastrinemia resolved, and the pituitary returned to normal size, with regrowth of the sella floor. The carcinoid tumor was shown by immunoperoxidase staining to contain GH-releasing hormone.

Received July 6, 1983.