| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
,
A. SCHEEN,
P.J. LEFEBVRE and
A.S. LUYCKX
Division of Diabetes and Division of Clinical Pharmacology, Institute of Medicine, University of Liege, Liege, Belgium
Insulin-stimulated glucose disposal was investigated using the euglycemic hyperinsulinemic glucose clamp technique in six women with anorexia nervosa (27.3 ± 4.9 yr old;weight, 38.8 ± 6.6 kg) and compared to results obtained in sixnormal women (22.6 ± 1.2 yr old; weight, 58 ± 2.5 kg) and sevenobese women (26.8 ± 7.7 yr old; weight, 92.5 ± 13.8 kg). Theglucose clamp was performed for 2 h using the Biostator and acontinuous insulin infusion of 100 mU kg,1 h,1. Plasma levelsof insulin were determined at 30-min intervals. Plasma levels ofglucagon, FFA, glycerol, 3-hydroxy-butyrate, and alanine weremeasured basally. Blood glucose levels were similar in normalsubjects and anorectic patients; they were slightly but significantlyhigher in the obese patients. The indices of insulinsensitivity measured were the MCR of glucose and the ratio ofglucose infused to insulin infused (G/I). They were very similarin anorectic subjects ±MCR, 13.5 ± 2.4 (±SEM) ml kg,1 min,1;G/I, 5.2 ± 0.9 mg/mU) and normal subjects (MCR, 13.5 ± 1.7ml kg"1 min,1; G/I, 5.2 ± 0.4 mg/mU), but were significantlyreduced in obese patients (MCR, 5.1 ± 0.8 ml kg,1 min,1; G/I,2.6 ± 0.3 mg/mU; P < 0.0025). Differences in plasma insulinamong the three groups were not statistically significant. Plasmaalanine levels were higher in anorectic than in normal or obesesubjects, suggesting defective gluconeogenesis. Thus, insulin stimulated glucose disposal is normal in patients with anorexianervosa, a finding that contrasts with the previously reportedincrease in erythrocyte insulin receptors in this disease. (J ClinEndocrinol Metab60: 311, 1985)
* This work was supported by grants from the Fonds de la Recherche Scientifique Medicale (FRSM) of Belgium
Department of Physiology and Biochemistry, University of Granada, Spain.
Received April 5, 1984.
This article has been cited by other articles:
![]() |
I. Dostalova, P. Kavalkova, D. Haluzikova, Z. Lacinova, M. Mraz, H. Papezova, and M. Haluzik Plasma Concentrations of Fibroblast Growth Factors 19 and 21 in Patients with Anorexia Nervosa J. Clin. Endocrinol. Metab., September 1, 2008; 93(9): 3627 - 3632. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Pannacciulli, R. Vettor, G. Milan, M. Granzotto, A. Catucci, G. Federspil, P. De Giacomo, R. Giorgino, and G. De Pergola Anorexia Nervosa Is Characterized by Increased Adiponectin Plasma Levels and Reduced Nonoxidative Glucose Metabolism J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1748 - 1752. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Yasuhara, T. Naruo, N. Nagai, M. Tanaka, T. Muranaga, and S.-i. Nozoe Insulinogenic index at 15 min as a marker of nutritional rehabilitation in anorexia nervosa Am. J. Clinical Nutrition, February 1, 2003; 77(2): 292 - 299. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |