help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

Journal of Clinical Endocrinology & Metabolism Vol. 60, No. 2 239-243
doi:10.1210/jcem-60-2-239
Copyright © 1985 by the Endocrine Society.
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SINHA, Y. N.
Right arrow Articles by MARKOFF, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SINHA, Y. N.
Right arrow Articles by MARKOFF, E.

Cleaved Prolactin: Evidence for Its Occurrence in Human Pituitary Gland and Plasma*

Y. N. SINHA, T. A. GILLIGAN, D. W. LEE, D. HOLLINGSWORTH and E. MARKOFF

Lutcher Brown Department of Biochemistry, The Whittier Institute for Diabetes and Endocrinology La olla, California 92037
The Department of Reproductive Medicine, University of California-San Diego La Jolla, California 92093

Address requests for reprints to: Dr. Y. N. Sinha, Luther Brown Department of Biochemistry, The Whittier Institute for Diabetes and Endocrinology, La Jolla, California 92037.

A form of PRL that is cleaved in its large disul-fide loop has been reported in rat and mouse pituitary glands, but it is not known whether it exists in the human pituitary gland and whether it circulates in blood. Recently, we developed an immunoelectrophoretic technique which is capable of measuring immunoreactive variants of PRL and other hormones in plasma. We describe here detection of cleaved PRL in normal and tumor pituitary tissue from a prolactinoma patient and in the plasma of pregnant women.

* This work was supported by PHS Grants CA-33448 and AM-32311.

Received February 10, 1984.




This article has been cited by other articles:


Home page
EndocrinologyHome page
M. E. Cruz-Soto, G. Cosio, M. C. Jeziorski, V. Vargas-Barroso, M. B. Aguilar, A. Carabez, P. Berger, P. Saftig, E. Arnold, S. Thebault, et al.
Cathepsin D Is the Primary Protease for the Generation of Adenohypophyseal Vasoinhibins: Cleavage Occurs within the Prolactin Secretory Granules
Endocrinology, December 1, 2009; 150(12): 5446 - 5454.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
S.-h. Lee, M. Nishino, T. Mazumdar, G. E. Garcia, M. Galfione, F. L. Lee, C. L. Lee, A. Liang, J. Kim, L. Feng, et al.
16-kDa Prolactin Down-Regulates Inducible Nitric Oxide Synthase Expression through Inhibition of the Signal Transducer and Activator of Transcription 1/IFN Regulatory Factor-1 Pathway
Cancer Res., September 1, 2005; 65(17): 7984 - 7992.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
C. Gonzalez, A. M. Corbacho, J. P. Eiserich, C. Garcia, F. Lopez-Barrera, V. Morales-Tlalpan, A. Barajas-Espinosa, M. Diaz-Munoz, R. Rubio, S.-H. Lin, et al.
16K-Prolactin Inhibits Activation of Endothelial Nitric Oxide Synthase, Intracellular Calcium Mobilization, and Endothelium-Dependent Vasorelaxation
Endocrinology, December 1, 2004; 145(12): 5714 - 5722.
[Abstract] [Full Text] [PDF]


Home page
Mol. Endocrinol.Home page
D. Piwnica, P. Touraine, I. Struman, S. Tabruyn, G. Bolbach, C. Clapp, J. A. Martial, P. A. Kelly, and V. Goffin
Cathepsin D Processes Human Prolactin into Multiple 16K-Like N-Terminal Fragments: Study of Their Antiangiogenic Properties and Physiological Relevance
Mol. Endocrinol., October 1, 2004; 18(10): 2522 - 2542.
[Abstract] [Full Text] [PDF]


Home page
IOVSHome page
H. Pan, N.-Q.-N. Nguyen, H. Yoshida, F. Bentzien, L. C. Shaw, F. Rentier-Delrue, J. A. Martial, R. Weiner, I. Struman, and M. B. Grant
Molecular Targeting of Antiangiogenic Factor 16K hPRL Inhibits Oxygen-Induced Retinopathy in Mice
Invest. Ophthalmol. Vis. Sci., July 1, 2004; 45(7): 2413 - 2419.
[Abstract] [Full Text] [PDF]


Home page
Endocr. Rev.Home page
H. E. Turner, A. L. Harris, S. Melmed, and J. A. H. Wass
Angiogenesis in Endocrine Tumors
Endocr. Rev., October 1, 2003; 24(5): 600 - 632.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
J. Kim, W. Luo, D.-T. Chen, K. Earley, J. Tunstead, L.-Y. Yu-Lee, and S.-H. Lin
Antitumor Activity of the 16-kDa Prolactin Fragment in Prostate Cancer
Cancer Res., January 15, 2003; 63(2): 386 - 393.
[Abstract] [Full Text] [PDF]


Home page
Physiol. Rev.Home page
M. E. Freeman, B. Kanyicska, A. Lerant, and G. Nagy
Prolactin: Structure, Function, and Regulation of Secretion
Physiol Rev, October 1, 2000; 80(4): 1523 - 1631.
[Abstract] [Full Text] [PDF]


Home page
J. Clin. Endocrinol. Metab.Home page
H. E. Turner, Z. Nagy, K. C. Gatter, M. M. Esiri, A. L. Harris, and J. A. H. Wass
Angiogenesis in Pituitary Adenomas and the Normal Pituitary Gland
J. Clin. Endocrinol. Metab., March 1, 2000; 85(3): 1159 - 1162.
[Abstract] [Full Text]


Home page
EndocrinologyHome page
S. Khurana, K. Liby, A. R. Buckley, and N. Ben-Jonathan
Proteolysis of Human Prolactin: Resistance to Cathepsin D and Formation of a Nonangiostatic, C-Terminal 16K Fragment by Thrombin
Endocrinology, September 1, 1999; 140(9): 4127 - 4132.
[Abstract] [Full Text]


Home page
JNCI J Natl Cancer InstHome page
S. E. Hankinson, W. C. Willett, D. S. Michaud, J. E. Manson, G. A. Colditz, C. Longcope, B. Rosner, and F. E. Speizer
Plasma Prolactin Levels and Subsequent Risk of Breast Cancer in Postmenopausal Women
J Natl Cancer Inst, April 7, 1999; 91(7): 629 - 634.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
Y.-F. Wang, J.-W. Liu, M. Mamidi, and A. M. Walker
Identification of the Major Site of Rat Prolactin Phosphorylation as Serine 177
J. Biol. Chem., February 2, 1996; 271(5): 2462 - 2469.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1985 by The Endocrine Society