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Journal of Clinical Endocrinology & Metabolism, Vol 59, 1025-1026, Copyright © 1984 by Endocrine Society

ARTICLES

Blockade of hp-GRF-40-induced GH release in normal men by a cholinergic muscarinic antagonist

F Massara, E Ghigo, S Goffi, GM Molinatti, EE Muller and F Camanni

In five healthy young men, pretreatment with the cholinergic muscarinic antagonist pirenzepine (0.6 mg/kg iv) almost completely abolished the rise in plasma growth hormone (GH) elicited by an iv bolus injection of 1 microgram/kg human pancreatic GH-releasing factor 1-40 (hp-GRF-40). These data demonstrate that cholinergic receptor sites involved in GH- releasing mechanisms do not interact with GRF-secreting structures in the central nervous system. A mechanism mediated via hypothalamic release of somatostatin or, alternatively, a direct pituitary site of action, can be postulated for the blocking effect of pirenzepine.




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Copyright © 1984 by The Endocrine Society