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Journal of Clinical Endocrinology & Metabolism, Vol 59, 1002-1005, Copyright © 1984 by Endocrine Society

ARTICLES

Acromegaly and Zollinger-Ellison syndrome secondary to an islet cell tumor: characterization and quantification of plasma and tumor human growth hormone-releasing factor

DM Wilson, GP Ceda, DG Bostwick, RJ Webber, JR Minkoff, A Pont, RL Hintz, KG Bensch, FB Kraemer and RG Rosenfeld

A young woman with acromegaly and Zollinger-Ellison syndrome associated with a GH-releasing factor (GRF)- and gastrin-secreting metastatic islet cell carcinoma was studied by means of specific antisera which recognize various regions of the GRF molecule. Using specific immunohistochemical techniques, the tumor cells were shown to contain GRF, gastrin, and gastrin-releasing peptide, but not GH. During a 4-h period, plasma GRF levels averaged 5.6 +/- 1.4 ng/ml (+/- SD), while GH levels averaged 148 +/- 71 ng/ml. GH secretion was pulsatile and increased after TRH administration. GRF RIAs may be useful in establishing the diagnosis of acromegaly secondary to the ectopic secretion of GRF.




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Copyright © 1984 by The Endocrine Society