help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Journal of Clinical Endocrinology & Metabolism Vol. 59, No. 4 812-814
doi:10.1210/jcem-59-4-812
Copyright © 1984 by the Endocrine Society.
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ATSUSHI, S.
Right arrow Articles by DOROTHY, T.K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ATSUSHI, S.
Right arrow Articles by DOROTHY, T.K.

IMMUNOREACTIVE CORTICOTROPIN-RELEASING FACTOR IS PRESENT IN HUMAN MATERNAL PLASMA DURING THE THIRD TRIMESTER OF PREGNANCY

SASAKI ATSUSHI, S. LIOTTA ANTHONY, M. LUCKEY MARJORIE, N. MARGIORIS ANDREW, SUDA TOSHIHIRO and T.KRIEGER DOROTHY

Division of Endocrinology, Department of Medicine Mount Sinai Medical Center, New York, New York 10029
Department of Obstetrics and Gynecology Mount Sinai Medical Center, New York, New York 10029
Department of Medicine Tokyo Women's Medical College, Tokyo 162, Japan

Immunoreactive (IR) corticotropin-releasing factor (CRF)-like activity was detectable in the majority of plasma samples obtained from women in the third trimester of pregnancy (68.7 ± 23.6 pg/ml(14.4 ± 4.9 fmol/ml); mean ± SE, n=15), but not in plasma (<10 pg/ml) from first (n=9) or second (n=ll) trimester of pregnancy, 1 day post partum (n=7), non-pregnant women (n=10), or in plasma obtained from patients with Cushing's disease (n=2) or Nelson's syndrome (n=l), or in basal (n=6) or ether-stressed (n=6) rat plasma. Gel filtration of third trimester pooled plasma revealed that the majority of such material eluted with Kav of rat CRF(1–41). The IR CRF(1–41)-sized material eluted with the identical retention time as rat CRF in a reverse phase high performance liquid chromatography (HPLC) system. The detection of IR CRF exclusively in third trimester maternal plasma, together with our previous demonstration that material physicochemically indistinguishable from it is present in human term placental extracts, suggests that the placenta may be the source of plasma IR CRF.

Received June 7, 1984.




This article has been cited by other articles:


Home page
 Arch Gen PsychiatryHome page
I. S. Yim, L. M. Glynn, C. Dunkel Schetter, C. J. Hobel, A. Chicz-DeMet, and C. A. Sandman
Risk of Postpartum Depressive Symptoms With Elevated Corticotropin-Releasing Hormone in Human Pregnancy
Arch Gen Psychiatry, February 1, 2009; 66(2): 162 - 169.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
M.P. Johnson, E. Fitzpatrick, T.D. Dyer, J.B.M. Jowett, S.P. Brennecke, J. Blangero, and E.K. Moses
Identification of two novel quantitative trait loci for pre-eclampsia susceptibility on chromosomes 5q and 13q using a variance components-based linkage approach
Mol. Hum. Reprod., January 1, 2007; 13(1): 61 - 67.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. R. Lindsay and L. K. Nieman
The Hypothalamic-Pituitary-Adrenal Axis in Pregnancy: Challenges in Disease Detection and Treatment
Endocr. Rev., October 1, 2005; 26(6): 775 - 799.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
W. J. Inder, T. C. R. Prickett, M. J. Ellis, L. Hull, R. Reid, P. S. Benny, J. H. Livesey, and R. A. Donald
The Utility of Plasma CRH as a Predictor of Preterm Delivery
J. Clin. Endocrinol. Metab., December 1, 2001; 86(12): 5706 - 5710.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
G. Gross, T. Imamura, and L. J. Muglia
Gene Knockout Mice in the Study of Parturitions
Reproductive Sciences, March 1, 2000; 7(2): 88 - 95.
[Abstract] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. Smith, S. Mesiano, E.-C. Chan, S. Brown, and R. B. Jaffe
Corticotropin-Releasing Hormone Directly and Preferentially Stimulates Dehydroepiandrosterone Sulfate Secretion by Human Fetal Adrenal Cortical Cells
J. Clin. Endocrinol. Metab., August 1, 1998; 83(8): 2916 - 2920.
[Abstract] [Full Text]

Home page
 Endocr. Rev.Home page
S. Mesiano and R. B. Jaffe
Developmental and Functional Biology of the Primate Fetal Adrenal Cortex
Endocr. Rev., June 1, 1997; 18(3): 378 - 403.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. J. Woods, C. F. Kemp, J. David, and P. J. Lowry
Heterogeneity of the Human Corticotropin-Releasing Factor-Binding Protein
J. Clin. Endocrinol. Metab., May 1, 1997; 82(5): 1566 - 1571.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
J. Lisansky, G. T. Peake, R. J. Strassman, C. Qualls, A. W. Meikle, S. C. Risch, G. A. Fava, M. Zownir-Brazis, P. Hochla, and D. Britton
Augmented Pituitary Corticotropin Response to a Threshold Dosage of Human Corticotropin-Releasing Hormone in Depressives Pretreated With Metyrapone
Arch Gen Psychiatry, July 1, 1989; 46(7): 641 - 649.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1984 by The Endocrine Society