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Isolated Growth Hormone Deficiency: Immunocytochemistry^*

Department of Anatomy and Cell Biology University of Southern California School of Medicine, Los Angeles, California 90033
Department of Pathology St. Michael's Hospital, University of Toronto, Ontario, Canada M5B 1W8
Division of Medical Genetics Departments of Pediatrics and Medicine, Harbor-UCLA Medical Center, Torrance, California 90509

Address requests for reprints to: Dr. Joel Schechter, Department of Anatomy and Cell Biology, University of Southern California School of Medicine, 1333 San Pablo Street, Los Angeles, California 90033.

Light and electron microscopic immunocytochemistry of the pituitary gland of a patient with documented isolated GH deficiency revealed parenchyma rich in GH positive cells. Immunoprecipitate was localized consistently over membrane-enclosed secretory granules whose features were characteristic of those in normal somatotrophs. No profiles of exocytosis of the contents of the secretory granules were observed. These observations demonstrate that the type I recessive form of isolated GH deficiency may be associated with apparently normal appearing somatotrophs which contain immunoreactive GH.

^* This work was supported by Grant R01-CA-21426 from the National Cancer Institute.

Received May 22, 1984.

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