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Journal of Clinical Endocrinology & Metabolism, Vol 59, 794-797, Copyright © 1984 by Endocrine Society

ARTICLES

The growth hormone response to thyrotropin-releasing hormone in insulin- dependent diabetics involves a cholinergic mechanism

P Chiodera, V Coiro, G Speroni, L Capretti, P Muzzetto, R Volpi and U Butturini

In order to establish whether cholinergic receptors mediate GH secretion induced by TRH in insulin-dependent diabetes, 10 patients were treated with pirenzepine, an anticholinergic agent, and tested with TRH. Basal concentrations of GH were elevated in these patients and 8 of 10 patients responded to TRH with a significant rise in GH levels. Pretreatment with pirenzepine (40 mg given iv 10 min before TRH) suppressed the TRH-induced GH rise. Pirenzepine had no effect on TRH-induced TSH release. This finding suggests that a cholinergic mechanism is involved in the paradoxical response of GH to TRH in diabetic patients.




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Copyright © 1984 by The Endocrine Society