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Journal of Clinical Endocrinology & Metabolism, Vol 59, 432-435, Copyright © 1984 by Endocrine Society

ARTICLES

Identification of immunoreactive thyrotropin-releasing hormone in human neoplasia

JF Wilber and P Spinella

Immunoreactive TRH (IR-TRH) was identified in extracts derived from seven human cancer tissues, including two oat cell carcinomas. The IR- TRH concentrations ranged from 29-189 pg/g. Tumor IR-TRH exhibited immunological identity with synthetic pyroglu-his-proamide and coeluted with synthetic [3H]TRH after high pressure liquid chromatography on a mu Bondapak C-18 column. These data extend the number of hypothalamic peptide hormones identified in human neoplastic tissues.


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[Abstract] [Full Text] [PDF]


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