help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jackson, R. A.
Right arrow Articles by Eisenbarth, G. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jackson, R. A.
Right arrow Articles by Eisenbarth, G. S.

Journal of Clinical Endocrinology & Metabolism, Vol 59, 187-190, Copyright © 1984 by Endocrine Society

ARTICLES

Ia+ T cells in new onset Graves' disease

RA Jackson, BF Haynes, WM Burch, K Shimizu, MA Bowring and GS Eisenbarth

The Ia (immune-associated, DR) antigen is a cell surface glycoprotein which is absent on normal circulating T lymphocytes but present on activated T lymphocytes. We studied the expression of this antigen on circulating T lymphocytes from patients with untreated hyperthyroid Graves' disease. All patients (n = 33) with recent onset hyperthyroid Graves' disease studied had an increased percentage and number of circulating Ia+ T cells. Patients with non-Graves's hyperthyroidism or Graves' disease patients more than 1 yr after thyroid ablation had normal values for Ia+ T cells. Other cell surface activation antigens, recognized by monoclonal antibodies 4F2 and 5E9, were not present on circulating T cells in patients with Graves' disease. The 100% positivity for increased numbers of Ia antigen-bearing T cells in hyperthyroid Graves' disease contrasts with our finding of 70% positivity in another HLA-DR-associated disease, recent onset type I diabetes mellitus. The pathogenic significance of these cells is not known, but they seem to represent selective activation of the immune system in patients with untreated hyperthyroid Graves' disease.


This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
B. S. Prabhakar, R. S. Bahn, and T. J. Smith
Current Perspective on the Pathogenesis of Graves' Disease and Ophthalmopathy
Endocr. Rev., December 1, 2003; 24(6): 802 - 835.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
S.N. Kalantaridou, D.T. Braddock, N.J. Patronas, and L.M. Nelson
Treatment of autoimmune premature ovarian failure: Case report
Hum. Reprod., July 1, 1999; 14(7): 1777 - 1782.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
A. Hoek, J. Schoemaker, and H. A. Drexhage
Premature Ovarian Failure and Ovarian Autoimmunity
Endocr. Rev., February 1, 1997; 18(1): 107 - 134.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1984 by The Endocrine Society