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Journal of Clinical Endocrinology & Metabolism, Vol 59, 142-146, Copyright © 1984 by Endocrine Society

ARTICLES

Transient neonatal hypothyroidism due to maternal immunoglobulins that inhibit thyrotropin-binding and post-receptor processes

N Takasu, T Mori, Y Koizumi, S Takeuchi and T Yamada

Transient neonatal hypothyroidism was found in a daughter of a 25-yr- old mother, who was receiving treatment for primary hypothyroidism due to Hashimoto's thyroiditis. During the neonatal period the infant had antithyroid microsomal and antithyroglobulin antibodies and TSH- receptor antibodies. The daughter recovered spontaneously from the hypothyroid state and the antithyroid antibodies disappeared from her serum. The mother's serum contained the same antibodies, and immunoglobulin G (IgG) from maternal serum blocked TSH binding to its receptors, TSH-stimulated cAMP responses, and cAMP-stimulated iodine uptake and organification in cultured thyroid cells. The latter finding suggests that the IgG had a postreceptor locus of action as well as inhibiting TSH binding to its receptor. The presence of such IgGs might have induced hypothyroidism both in the mother and in the daughter.


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B. Rapoport, G. D. Chazenbalk, J. C. Jaume, and S. M. McLachlan
The Thyrotropin (TSH)-Releasing Hormone Receptor: Interaction with TSH and Autoantibodies
Endocr. Rev., December 1, 1998; 19(6): 673 - 716.
[Abstract] [Full Text]

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 CLIN PEDIATRHome page
N.A. Kulaylat and S.S. Najjar
Transient Primary Hypothyroidism in Prematures
Clinical Pediatrics, July 1, 1987; 26(7): 339 - 342.
[Abstract] [PDF]


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