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Journal of Clinical Endocrinology & Metabolism, Vol 58, 582-584, Copyright © 1984 by Endocrine Society

ARTICLES

Prolonged elevation of hypothalamic opioid peptide activity in women taking oral contraceptives

RF Casper, R Bhanot and M Wilkinson

To examine the hypothesis that endogenous opioid peptide activity is chronically elevated by oral contraceptives, we infused either naloxone or saline into 10 women during the use of, or 5-6 and 9-10 days after stopping, combination birth control pills. A paradoxical increase in prolactin occurred with naloxone infusion during and 5-6 days after stopping the pills. Serum LH levels were not significantly elevated by naloxone until 9-10 days after cessation of pill use. These results suggest that hypothalamic opioid peptide activity is continuously elevated in women taking oral contraceptives.




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Copyright © 1984 by The Endocrine Society