help button home button Endocrine Society JCEM JCEM Call for Nominations for EIC
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Conaglen, J. V.
Right arrow Articles by Nicholls, M. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Conaglen, J. V.
Right arrow Articles by Nicholls, M. G.

Journal of Clinical Endocrinology & Metabolism, Vol 58, 463-466, Copyright © 1984 by Endocrine Society

ARTICLES

The effect of ovine corticotropin-releasing factor on catecholamine, vasopressin, and aldosterone secretion in normal man

JV Conaglen, RA Donald, EA Espiner, JH Livesey and MG Nicholls

The 41-residue ovine corticotropin-releasing factor (CRF) was administered iv to five normal men. A significant rise in plasma corticotropin (ACTH), cortisol, and aldosterone was demonstrated after a dose of 200 micrograms. There was no demonstrable change in supine blood pressure, pulse rate, plasma vasopressin, renin, catecholamines, insulin, glucagon, or glucose. It is concluded that 200 micrograms ovine CRF stimulates ACTH and cortisol secretion independently of any change in peripheral plasma levels of vasopressin and catecholamines. The cortisol and ACTH responses to ovine CRF were less marked but more prolonged than those after insulin-induced hypoglycemia. The relatively small increment in plasma ACTH, which was well within the physiological range, was associated with a significant increase in plasma aldosterone. Posterior pituitary function was not affected by this dose of ovine CRF.


This article has been cited by other articles:


Home page
 Eur J EndocrinolHome page
G. Mastorakos, E. I Karoutsou, and M. Mizamtsidi
Corticotropin releasing hormone and the immune/inflammatory response
Eur. J. Endocrinol., November 1, 2006; 155(suppl_1): S77 - S84.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
G. MASTORAKOS and I. ILIAS
Maternal and Fetal Hypothalamic-Pituitary-Adrenal Axes During Pregnancy and Postpartum
Ann. N.Y. Acad. Sci., November 1, 2003; 997(1): 136 - 149.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1984 by The Endocrine Society